Allison Ashley-Koch

Cheryl Ann Teh

James MacFall

John Beyer

Margaratha Kuchibhatla

Ranga Krishnan

Tih-Shih Lee

Yu-Feng Zang

PLoS ONE

PubMed

In this study of the effect of bipolar status and presence of BDNF Val66Met polymorphism on differences in regional brain volumes, we hypothesized based on previous studies that 1) bipolar subjects will have smaller regional brain volumes than healthy controls; 2) BDNF Met66 allele carriers within the same population are likely to have smaller regional brain volumes as compared to Val66 homozygyotes. In our Caucasian sample of 166 bipolar subjects and 64 gender-matched healthy controls, we found significant decreases in total (p = 0.005) and regional gray matter volumes in bipolar patients compared to healthy controls, more pronounced in the inferior and posterior parts of the brain, together with a concomitant increase in total CSF (p = 0.012) particularly in the lateral ventricles (p = 0.023). However, there was no difference in white matter volumes noted by other studies. Furthermore we did not find significant differences in other brain regions that have been reported by other authors. Nor did we find a significant effect of BDNF on these measurements

Tih-shih Lee

Allison Ashley-koch

James Macfall

CiteSeerX

Bipolar Disorder, Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Brain Morphology

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Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.

Teh Cheryl Ann

Lee Tih-Shih

Kuchibhatla Margaratha

Ashley-Koch Allison

MacFall James

Krishnan Ranga

Beyer John

Public Library of Science (PLOS)

Crossref

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White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies.

http://dx.doi.org/10.1371/journal.pone.0038469

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology

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Public Library of Science (PLOS)

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