10.1371/journal.pone.0093755PLoS ONE94-POLN

A Giordano

A Niwinska

AR Donders

BH Ly

C Nieder

CH Nash 3rd

CH Yip

Cheng-Har Yip

CI Li

D Moher

D Rades

E Biganzoli

E Rapiti

E von Elm

Ern-Yu Tan

EY Tan

F Andre

FE Harrell Jr

G Agarwal

GN Hortobagyi

Helena M. Verkooijen

HK Ahn

Hoong-Seam Wong

Hui Miao

J Chang

J Ferlay

J O'Shaughnessy

J Ruiterkamp

JA Perez-Fidalgo

Jeremy Goh

JF Robertson

JH Todd

JS Michaelson

Karel G. M. Moons

L Gordon

LF Degner

M Balic

M Cristofanilli

M Rabinovich

M Ryberg

M Sant

M Todd

Mikael Hartman

ML Telli

MR Williams

MT Liu

N Bhoo-Pathy

N Yamamoto

NB Pathy

NF Marko

Nirmala Bhoo-Pathy

Nur Aishah Taib

P Glare

P Tai

Patrick Chan

PM Ravdin

PW Sperduto

R Chopra

R Largillier

R Le Scodan

SE Lim

Siti Mastura Rahim

SK Chia

SK Pal

Soo-Chin Lee

Syed A. Aziz

V Muller

W Khodari

PubMed

Crossref

PLoS ONE

Predicting Survival of De Novo Metastatic Breast Cancer in Asian Women: Systematic Review and Validation Study

<div>BackgroundIn Asia, up to 25% of breast cancer patients present with distant metastases at diagnosis. Given the heterogeneous survival probabilities of de novo metastatic breast cancer, individual outcome prediction is challenging. The aim of the study is to identify existing prognostic models for patients with de novo metastatic breast cancer and validate them in Asia.Materials and MethodsWe performed a systematic review to identify prediction models for metastatic breast cancer. Models were validated in 642 women with de novo metastatic breast cancer registered between 2000 and 2010 in the Singapore Malaysia Hospital Based Breast Cancer Registry. Survival curves for low, intermediate and high-risk groups according to each prognostic score were compared by log-rank test and discrimination of the models was assessed by concordance statistic (C-statistic).ResultsWe identified 16 prediction models, seven of which were for patients with brain metastases only. Performance status, estrogen receptor status, metastatic site(s) and disease-free interval were the most common predictors. We were able to validate nine prediction models. The capacity of the models to discriminate between poor and good survivors varied from poor to fair with C-statistics ranging from 0.50 (95% CI, 0.48–0.53) to 0.63 (95% CI, 0.60–0.66).ConclusionThe discriminatory performance of existing prediction models for de novo metastatic breast cancer in Asia is modest. Development of an Asian-specific prediction model is needed to improve prognostication and guide decision making.</div

Hui Miao (143177)

Mikael Hartman (77255)

Nirmala Bhoo-Pathy (132899)

Soo-Chin Lee (132913)

Nur Aishah Taib (132905)

Ern-Yu Tan (545867)

Patrick Chan (545868)

Karel G. M. Moons (112759)

Hoong-Seam Wong (545869)

Jeremy Goh (545870)

Siti Mastura Rahim (545871)

Cheng-Har Yip (132895)

Helena M. Verkooijen (132915)

The Francis Crick Institute

Predicting Survival of De Novo Metastatic Breast Cancer in Asian Women: Systematic Review and Validation Study

 metastatic breast cancer and validate them in Asia. metastatic breast cancer registered between 2000 and 2010 in the Singapore Malaysia Hospital Based Breast Cancer Registry. Survival curves for low, intermediate and high-risk groups according to each prognostic score were compared by log-rank test and discrimination of the models was assessed by concordance statistic (C-statistic).We identified 16 prediction models, seven of which were for patients with brain metastases only. Performance status, estrogen receptor status, metastatic site(s) and disease-free interval were the most common predictors. We were able to validate nine prediction models. The capacity of the models to discriminate between poor and good survivors varied from poor to fair with C-statistics ranging from 0.50 (95% CI, 0.48–0.53) to 0.63 (95% CI, 0.60–0.66). metastatic breast cancer in Asia is modest. Development of an Asian-specific prediction model is needed to improve prognostication and guide decision making

Miao Hui

Hartman Mikael

Bhoo-Pathy Nirmala

Lee Soo-Chin

Taib Nur Aishah

Tan Ern-Yu

Chan Patrick

Moons Karel G. M.

Wong Hoong-Seam

Goh Jeremy

Rahim Siti Mastura

Yip Cheng-Har

Verkooijen Helena M.

Public Library of Science (PLOS)

 Metastatic Breast Cancer in Asian Women: Systematic Review and Validation Study

BackgroundIn Asia, up to 25% of breast cancer patients present with distant metastases at diagnosis. Given the heterogeneous survival probabilities of de novo metastatic breast cancer, individual outcome prediction is challenging. The aim of the study is to identify existing prognostic models for patients with de novo metastatic breast cancer and validate them in Asia.Materials and methodsWe performed a systematic review to identify prediction models for metastatic breast cancer. Models were validated in 642 women with de novo metastatic breast cancer registered between 2000 and 2010 in the Singapore Malaysia Hospital Based Breast Cancer Registry. Survival curves for low, intermediate and high-risk groups according to each prognostic score were compared by log-rank test and discrimination of the models was assessed by concordance statistic (C-statistic).ResultsWe identified 16 prediction models, seven of which were for patients with brain metastases only. Performance status, estrogen receptor status, metastatic site(s) and disease-free interval were the most common predictors. We were able to validate nine prediction models. The capacity of the models to discriminate between poor and good survivors varied from poor to fair with C-statistics ranging from 0.50 (95% CI, 0.48-0.53) to 0.63 (95% CI, 0.60-0.66).ConclusionThe discriminatory performance of existing prediction models for de novo metastatic breast cancer in Asia is modest. Development of an Asian-specific prediction model is needed to improve prognostication and guide decision making

Karel G M Moons

Helena M Verkooijen

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Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study.

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Predicting survival of de novo metastatic breast cancer in Asian women: Systematic review and validation study

Predicting survival of de novo metastatic breast cancer in Asian women: Systematic review and validation study

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The Francis Crick Institute

Public Library of Science (PLOS)

Directory of Open Access Journals

Public Library of Science (PLOS)