10.1371/journal.pone.0085149PLoS ONE91-POLN

A Berrington de Gonzalez

A Seow

AA Arsian

Ai Zhen Jin

Andrew O. Odegaard

AO Odegaard

AR Hart

AV Patel

C Samanic

CA Conover

Consultation WHO Expert

D Albanes

DM Parkin

DS Michaud

E Giovannucci

EE Calle

J Luo

J Ma

JE Manson

JH Hankin

Jian-Min Yuan

K Wada

KA Perkins

Kristin E. Anderson

L Jiao

LN Jiao Anderson

M Wang

P Deurenberg

R Durazo-Arizu

R LinY, Fu

RC Klesges

RJ Kuczmarski

RJ Stevens

RZ Stolzenberg-Solomon

S Connor Gorber

S Iodice

SC Larsson

Seema Untawale

SH Jee

SO Olusi

Suminori Akiba

U Nothlings

WH Tsong

Woon-Puay Koh

WP Koh

XH Lu

Y Lin

PLoS ONE

PubMed

Crossref

Body Mass Index and Risk of Pancreatic Cancer in a Chinese Population

Few studies have examined the association between body mass index (BMI: kg/m2) and pancreatic cancer risk in Asian populations. We examined this relationship in 51,251 Chinese men and women aged 45–74 who enrolled between 1993 and 1998 in the population based, prospective Singapore Chinese Health Study. Data were collected through in-person interviews. By December 31, 2011, 194 cohort participants had developed pancreatic cancer. A Cox proportional hazards model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). We hypothesized the association between BMI and pancreatic cancer risk may vary by smoking status (ever v. never) and there was evidence for this as the interaction between BMI and smoking status was significant (p = 0.018). Among ever smokers, being classified as underweight (BMI <18.5 kg/m2), was associated with a significantly elevated risk of pancreatic cancer relative to smokers with a BMI of 21.5–24.4 kg/m2 (HR = 1.99, 95% CI = 1.03–3.84). This association was strengthened after exclusion of the first three years of follow-up time. Among never smokers, there was no association between BMI and pancreatic cancer risk. However, after excluding pancreatic cancer cases and person-years in the first three years of follow-up, never smokers with a BMI ≥ 27.5 kg/m2 showed a suggestive increased risk of pancreatic cancer relative to never smokers with a BMI of 21.5–24.4 kg/m2 (HR = 1.75, 95% CI = 0.93–3.3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers

Untawale, Seema

Odegaard, Andrew O.

Koh, Woon-Puay

Jin, Ai Zhen

Yuan, Jian-Min

Anderson, Kristin E.

Name not available

Untawale Seema

Odegaard Andrew O.

Koh Woon-Puay

Jin Ai Zhen

Yuan Jian-Min

Anderson Kristin E.

Public Library of Science (PLOS)

Few studies have examined the association between body mass index (BMI: kg/m(2)) and pancreatic cancer risk in Asian populations. We examined this relationship in 51,251 Chinese men and women aged 45-74 who enrolled between 1993 and 1998 in the population based, prospective Singapore Chinese Health Study. Data were collected through in-person interviews. By December 31, 2011, 194 cohort participants had developed pancreatic cancer. A Cox proportional hazards model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). We hypothesized the association between BMI and pancreatic cancer risk may vary by smoking status (ever v. never) and there was evidence for this as the interaction between BMI and smoking status was significant (p = 0.018). Among ever smokers, being classified as underweight (BMI <18.5 kg/m(2)), was associated with a significantly elevated risk of pancreatic cancer relative to smokers with a BMI of 21.5-24.4 kg/m(2) (HR = 1.99, 95% CI  =  1.03-3.84). This association was strengthened after exclusion of the first three years of follow-up time. Among never smokers, there was no association between BMI and pancreatic cancer risk. However, after excluding pancreatic cancer cases and person-years in the first three years of follow-up, never smokers with a BMI ≥ 27.5 kg/m(2) showed a suggestive increased risk of pancreatic cancer relative to never smokers with a BMI of 21.5-24.4 kg/m(2) (HR  =  1.75, 95% CI  =  0.93-3.3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers

Andrew O Odegaard

Kristin E Anderson

Directory of Open Access Journals

Body mass index and risk of pancreatic cancer in a Chinese population.

Few studies have examined the association between body mass index (BMI: kg/m(2)) and pancreatic cancer risk in Asian populations. We examined this relationship in 51,251 Chinese men and women aged 45-74 who enrolled between 1993 and 1998 in the population based, prospective Singapore Chinese Health Study. Data were collected through in-person interviews. By December 31, 2011, 194 cohort participants had developed pancreatic cancer. A Cox proportional hazards model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). We hypothesized the association between BMI and pancreatic cancer risk may vary by smoking status (ever v. never) and there was evidence for this as the interaction between BMI and smoking status was significant (p = 0.018). Among ever smokers, being classified as underweight (BMI &lt;18.5 kg/m(2)), was associated with a significantly elevated risk of pancreatic cancer relative to smokers with a BMI of 21.5-24.4 kg/m(2) (HR = 1.99, 95% CI  =  1.03-3.84). This association was strengthened after exclusion of the first three years of follow-up time. Among never smokers, there was no association between BMI and pancreatic cancer risk. However, after excluding pancreatic cancer cases and person-years in the first three years of follow-up, never smokers with a BMI ≥ 27.5 kg/m(2) showed a suggestive increased risk of pancreatic cancer relative to never smokers with a BMI of 21.5-24.4 kg/m(2) (HR  =  1.75, 95% CI  =  0.93-3.3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers

Odegaard, Andrew O

Anderson, Kristin E

eScholarship - University of California

English

Few studies have examined the association between body mass index (BMI: kg/m2) and pancreatic cancer risk in Asian populations. We examined this relationship in 51,251 Chinese men and women aged 45-74 who enrolled between 1993 and 1998 in the population based, prospective Singapore Chinese Health Study. Data were collected through in-person interviews. By December 31, 2011, 194 cohort participants had developed pancreatic cancer. A Cox proportional hazards model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). We hypothesized the association between BMI and pancreatic cancer risk may vary by smoking status (ever v. never) and there was evidence for this as the interaction between BMI and smoking status was significant (p= 0.018). Among ever smokers, being classified as underweight (BMI <18.5 kg/m2), was associated with a significantly elevated risk of pancreatic cancer relative to smokers with a BMI of 21.5-24.4 kg/m 2 (HR=1.99, 95% CI = 1.03-3.84). This association was strengthened after exclusion of the first three years of follow-up time. Among never smokers, there was no association between BMI and pancreatic cancer risk. However, after excluding pancreatic cancer cases and person-years in the first three years of follow-up, never smokers with a BMI ≥ 27.5 kg/m2 showed a suggestive increased risk of pancreatic cancer relative to never smokers with a BMI of 21.5-24.4 kg/m2 (HR = 1.75, 95% CI = 0.93-3.3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers. © 2014 Untawale et al

Untawale, S

Odegaard, AO

Koh, WP

Jin, AZ

Yuan, JM

Anderson, KE

D-Scholarship@Pitt

Body mass index and risk of pancreatic cancer in a Chinese population

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Body mass index and risk of pancreatic cancer in a Chinese population

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