Ashraf Emran

Ashraf Mosharafa

Ayman Kamal

Baltacı S

Carver B

Feliciano J

Greene KL

Guercio S

Habermacher GM

Karazanashvili G

Kaygisiz O

Kobayashi M

Lorente JA

Mohammed Abdelhamid

Mohammed Torky

Nam RK

Nixon RG

Potts JM

Roehrbornab CG

Schaeffer AJ

Serretta V

Shariat SF

Shigehara K

Shimomura T

Shtricker A

Stancik I

Stopiglia RM

Terrone C

&lt;i&gt;Objectives:&lt;/i&gt; To assess the effects of a 4-week levofloxacin course on PSA in asymptomatic men with elevated prostate-specific antigen (PSA) and on prostate biopsy decision. &lt;i&gt;Methods:&lt;/i&gt; Fifty asymptomatic men with elevated PSA (4.0–10.0 ng/dl) were given levofloxacin 500 mg/day for 4 weeks followed by repeat PSA. Prostate biopsy was recommended at the end of the study. We compared pre- and post-treatment PSA as well as PSA changes between prostate cancer cases and non-cancer patients. &lt;i&gt;Results:&lt;/i&gt; Mean (±SD) PSA decreased from 6.91 ± 2.13 to 6.05 ± 3.0 ng/dl after antimicrobial treatment (p = 0.025). Twenty-five (56.8%) patients had a post-treatment decrease in PSA, including 20 (45.5%) patients to &lt;4.0 ng/dl and/or &gt;25% of the initial PSA value. The difference in PSA change between prostate cancer and non-cancer patients was not statistically significant (p = 0.104). &lt;i&gt;Conclusions:&lt;/i&gt; Levofloxacin resulted in an overall decrease in PSA for asymptomatic men with PSA in the 4–10 ng/dl range. PSA changes, however, were not significantly different between patients with prostate cancer and non-cancer patients. Prostate cancer was detected in 20% of patients with a clinically relevant PSA decline.</jats:p

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Urologia Internationalis

Antimicrobial Therapy for Asymptomatic Patients with Elevated Prostate-Specific Antigen: Can the Change in Prostate-Specific Antigen Reliably Guide Prostate Biopsy Decisions?

Antimicrobial Therapy for Asymptomatic Patients with Elevated Prostate-Specific Antigen: Can the Change in Prostate-Specific Antigen Reliably Guide Prostate Biopsy Decisions?

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