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长期砷暴露的大鼠尿液代谢组学研究
Authors
张博
朱珏
沈运旺
王晓飞
Publication date
14 March 2019
Publisher
Doi
Cite
Abstract
慢性无机砷暴露能够引发多种疾病和损害,但其所涉及的生物学过程尚未完全阐明。全球约有超过2亿人面临饮用水砷污染的威胁。本研究以自由饮水的方式对健康大鼠进行无机砷的长期暴露,并对大鼠尿液的代谢组变化进行系统分析。结果表明,长期砷暴露大鼠的尿液代谢组与对照组具有显著区别,且高剂量砷暴露对大鼠尿液代谢组产生的影响更加显著。本研究共鉴定出36种差异代谢物,其中14种与氨基酸代谢相关的代谢物发生了显著变化,涉及到色氨酸代谢、精氨酸和脯氨酸代谢、赖氨酸降解、β-丙氨酸代谢、半胱氨酸和蛋氨酸代谢、甘氨酸、丝氨酸和苏氨酸代谢;11种与脂类代谢相关的代谢物,涉及到的代谢通路有鞘脂代谢、脂肪酸代谢;同时发现蛋白质的表达与翻译后修饰也受到干扰。这些生物学过程的改变均可作为砷毒性机理的关键分子事件。国家自然科学基金项目(Nos.21475110,21535007,J1310024);;中国博士后基金项目(No.2018M642572);;厦门市科技计划项目(No.3502Z20173019);;中央高校基本科研业务费(No.20720160051)资
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Xiamen University Institutional Repository
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oai:dspace.xmu.edu.cn:2288/176...
Last time updated on 20/11/2020
Xiamen University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.xmu.edu.cn:2288/176...
Last time updated on 20/11/2020