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基于多色探针熔解曲线分析技术的华法林个体化用药相关基因多态性快速检测方法
Authors
夏众敏
李庆阁
洪国粦
黄秋英
Publication date
31 July 2019
Publisher
Abstract
华法林是一种广泛使用的抗凝剂,其治疗窗口较窄,患者达到抗凝所需剂量的变异性大.已有研究表明CYP2C9*3 (rs1057910)、CYP2C9IVS3-65G>C(rs9332127)、VKORC1 c.-1639G>A (rs9923231)和CYP4F2*3 (rs2108622)的单核苷酸多态性(SNPs)是影响中国人群华法林敏感性的主要遗传因素.该研究利用多色探针熔解曲线分析(MMCA)技术,建立可同时检测4个华法林敏感性基因多态性位点的单管PCR反应体系,可在2.5h内完成检测,每个反应能检测低至0.05ng的人基因组DNA.对218份厦门市随机人群的4类SNPs进行筛查及其中40份样本测序的结果表明,MMCA体系准确性高,厦门市人群的4类SNPs发生频率与此前报道的中国汉族人群的相近,其中rs1057910的等位基因A和C的频率分别为96.4%和3.6%,rs9332127的等位基因G和C的频率分别为96.4%和3.6%,rs9923231的等位基因G和A的频率分别为7.8%和92.2%,rs2108622的等位基因G和A的频率分别为75.7%和24.3%.上述基于MMCA技术的SNP分型体系具有快速、简便、准确、低成本等优点,适合在临床上推广用于指导华法林用药剂量.福建省高校杰出青年科研人才培育计划项目厦门市科技计划项目(3502Z20179044
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Xiamen University Institutional Repository
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oai:dspace.xmu.edu.cn:2288/175...
Last time updated on 20/11/2020
Xiamen University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.xmu.edu.cn:2288/175...
Last time updated on 20/11/2020