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雷公藤红素脂质体的制备及其对U87 MG肿瘤细胞增殖的抑制作用
Authors
杨钦磊
王秀敏
韩秋惠
Publication date
27 November 2019
Publisher
Abstract
建立雷公藤红素的高效液相色谱分析方法,采用薄膜分散法制备雷公藤红素脂质体,并通过正交实验优化处方,对雷公藤红素脂质体的粒径、Zeta电位、形态、体外释放度和体外对U87 MG肿瘤细胞增殖的抑制作用进行考察。结果显示雷公藤红素脂质体的体外分析方法简单可行,制备雷公藤红素脂质体最佳处方为:药脂质量比1:40,磷脂与胆固醇质量比6:1,水化介质为10%(质量分数)海藻糖溶液。最优处方制备的脂质体的粒径约160 nm,Zeta电位为-35 mV,包封率达到80%以上。体外释放实验表明雷公藤红素脂质体具有缓释作用,且雷公藤红素脂质体抑制U87 MG细胞增殖的作用强于雷公藤红素溶液,半抑制浓度(IC50)为7.93 μmol/L。综上,制备雷公藤红素脂质体的方法稳定可行,脂质体体理化性质良好并具有良好的抑制U87 MG肿瘤细胞增殖作用
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Last time updated on 20/11/2020