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环氧泽泻烯对2型糖尿病小鼠的降糖作用
Authors
刘华欣
张伟云
+3 more
王明军
王青
陈全成
Publication date
22 August 2019
Publisher
Abstract
目的探索环氧泽泻烯的降血糖活性。方法采用链脲佐菌素与烟酰胺建立2型糖尿病小鼠模型。腹腔注射链脲佐菌素与烟酰胺后的d 21测定血糖,d 22进行口服葡萄糖耐量试验。选择罗格列酮作为阳性对照药,每天按小鼠体重以10 mg·kg-1剂量灌胃给药,连续3周;环氧泽泻烯不同剂量组每天分别按小鼠体重以5、10、20 mg·kg-1剂量灌胃给药,连续3周。此外,采用油红O染色法探索了0.5、1μmol·L-1环氧泽泻烯对3T3-L1前脂肪细胞分化的影响。结果环氧泽泻烯不仅使2型糖尿病小鼠空腹血糖下降,而且在口服葡萄糖耐量试验期间也表现出降低血糖的趋势。在0.5、1μmol·L-1浓度下,环氧泽泻烯促进了3T3-L1前脂肪细胞分化过程。结论环氧泽泻烯可能具有降血糖活性,加速前脂肪细胞分化过程,其机制有待进一步研究。国家自然科学基金面上项目(No 81773601)福建省教育厅中青年教师教育科研项目(No JT180664)福建省卫生系统项目(No 2015-ZQN-JC-45)福建省中医药重点研究室项目(No ZD201405
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Xiamen University Institutional Repository
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oai:dspace.xmu.edu.cn:2288/174...
Last time updated on 20/11/2020
Xiamen University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.xmu.edu.cn:2288/174...
Last time updated on 20/11/2020