Can Animal Skin Diseases or Current Transgenic Mice Serve as a Model for Hidradenitis Suppurativa?

Abstract

The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of gamma-secretase mutations in a subpopulation of patients with HS suggested gamma-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic gamma-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model. Copyright (C) 2012 S. Karger AG, Base