We show that abstract interpretation-based static program analysis can be
made efficient and precise enough to formally verify a class of properties for
a family of large programs with few or no false alarms. This is achieved by
refinement of a general purpose static analyzer and later adaptation to
particular programs of the family by the end-user through parametrization. This
is applied to the proof of soundness of data manipulation operations at the
machine level for periodic synchronous safety critical embedded software. The
main novelties are the design principle of static analyzers by refinement and
adaptation through parametrization, the symbolic manipulation of expressions to
improve the precision of abstract transfer functions, the octagon, ellipsoid,
and decision tree abstract domains, all with sound handling of rounding errors
in floating point computations, widening strategies (with thresholds, delayed)
and the automatic determination of the parameters (parametrized packing)