Aderka D

Antoni Castro

Antonio Pérez

Begoña Lainez

Cristobal Richart

Georgina Peñarroja

Joan Vendrell

José-Manuel Fernandez-Real

Kahaleh MB

Mercedes Rigla

Mohler KM

Montserrat Broch

Olsson I

Pablo Engel

Piatti PM

Wifredo Ricart

Zinman B

 Tumor necrosis factor-α (TNF-α) is increasingly recognized as a key component in the development of insulin resistance and increased blood pressure. In a sample of 368 individuals, the ratio of soluble TNF-α receptors (sTNFR2/sTNFR1) correlated positively with systolic and diastolic blood pressure ( P &lt; 0.01). This ratio was significantly greater in type 2 diabetic subjects (DM-2) than in type 1 diabetic patients and was greater than in control nondiabetic subjects ( P &lt; 0.00001). The TNF-α receptor 1 (TNFR1) density in peripheral blood monocytes was similar in DM-2 patients and in nondiabetic subjects. After phorbol 12-myristate 13-acetate, TNFR1 shedding was significantly decreased in DM-2 compared with control subjects, and it was directly associated with insulin sensitivity ( r = 0.54, P = 0.03). Serum sTNFR1 concentration was also linked to the vasodilatory response to glyceryltrinitrate ( P = 0.01). Conversely, TNF-α receptor 2 shedding was negatively associated with insulin sensitivity ( r = −0.54, P = 0.03), whereas shedding of L-selectin showed no significant association. After exercise-induced lowering of blood pressure, a parallel decrease in sTNFR2/sTNFR1 was observed in DM-2 patients. Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-α receptors in DM-2. The latter seems reversible and is not genetically determined. </jats:p

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AJP Endocrinology and Metabolism

Shedding of TNF-α receptors, blood pressure, and  insulin sensitivity in type 2 diabetes mellitus

Shedding of TNF-α receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus

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