In Myanmar, the natural Spirulina platensis is produced from the natural lake of Yae Kharr lake. The aim of this research was to achieve silver and zinc oxide nanoparticles from Spirulina platensis and its utilizations in biomedical, waste water and balm, some lotions, and face cream for cosmetic products. Spirulina platenis (blue green algae) plays a very important role for health food. Silver and zinc oxide nanoparticles from Spirulina were obtained by green synthesis. Silver and zinc oxide nanoparticles from Spirulina were obtained by calcinations at 60º C and characterized by XRD, SEM, AFM and UV visible spectrophotometer techniques. Average crystallite size of silver and zinc oxide nanoparticles from Spirulina was found to be 23.93 nm and 12 nm by using Debye Scherer equation. The antimicrobial activity of silver and zinc oxide nanoparticles against both gram positive bacteria (Bacillus subtilis, Bacillus pulamis, Staphylococcus aureus, and gram negative bacteria ( Escherichia coli and Pseudomonas aeruginosa) and Candida albicans fungus strain were done by agar well diffusion method. Among these strains, Escherichia coli and Candida albicans showed the highest antimicrobial activity of silver and zinc oxide nanoparticles from Spirulina platensis. Rhodamine G dye was used as model solution and removal percent of Silver and zinc oxide nanoparticles were found to be 84.58% and 75. 12%. Silver and zinc oxide nanoparticles were applied and made for the formation of face cream, body lotion and balm. It was observed that these products can be used safely for body lotion, balm for skin and face cream because the pH value and microbial testing (total plate and yeast and mold counts) of these cosmetic products were found under acceptable level compared to literature values. The main advantages of zinc oxide nanoparticles coated with fabrics can be used in textile industry due to uniform distribution of nanoparticles on the fabric surface to obtain long elasticity