AD Karelis

AG Renehan

BJ Kim

C Voulgari

CK Kramer

CM Kitahara

CS Liu

EK Wei

F Soriguer

FJ Duijnhoven van

FM Mendonca

G Pergola De

G Vazquez

J Arnlov

JB Meigs

JC Hardwick

JH Kim

KE Yun

KG Alberti

N Murphy

Q Ben

RP Wildman

T Nishii

T Stocks

V Primeau

VW Wong

Y Wu

AbstractObesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Participants were classified as metabolically healthy if they had no metabolic syndrome component. Participants were categorized into four groups according to body mass index and metabolic status: metabolically healthy non-obese (MHNO; n = 2,745), metabolically abnormal non-obese (MANO; n = 3,267), metabolically healthy obese (MHO; n = 707), and metabolically abnormal obese (MAO; n = 2,612). MAO individuals [n = 159 advanced colorectal neoplasia (AN) cases, 6.1%] and MANO individuals (n = 167 AN cases, 5.1%) had a higher incidence of AN compared with MHNO individuals (n = 79 AN cases, 2.9%). In a multivariable model, the risk of metachronous AN was higher in MANO (hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.12–1.84) and MAO (HR 1.52, 95% CI 1.18–1.96) than in MHNO. In contrast, the risk of metachronous AN was not significantly elevated in MHO. In subgroup analyses, with or without adenoma at baseline, MAO was a risk group for metachronous AN, and MHO was not. Our findings suggest that metabolic unhealthiness is a significant predictor for metachronous AN.</jats:p

Tae Jun Kim

Eun Ran Kim

Sung Noh Hong

Young-Ho Kim

Dong Kyung Chang

Jaehwan Ji

Jee Eun Kim

Hye Seung Kim

Kyunga Kim

Hee Jung Son

Crossref

Scientific Reports

Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

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