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Early protein intake predicts functional connectivity and neurocognition in preterm born children
Authors
Jane Alsweiler
Jane M. Alsweiler
+26 more
Coila Bevan
Janene B. Biggs
Joanna M. Black
Frank H. Bloomfield
Emma G. Duerden
Kelly Fredell
Greg Gamble
Greg D. Gamble
Jane E. Harding
Jane E. Harding
Sabine Huth
Yannan Jiang
Yannan Jiang
Christine Kevan
Myra Leung
Myra Leung
Steven P. Miller
Geraint Phillips
Tanya Poppe
Tanya Poppe
Jennifer A. Rogers
Heather Stewart
Benjamin Thompson
Benjamin S. Thompson
Anna C. Tottman
Trecia Wouldes
Publication date
1 December 2021
Publisher
Scholarship@Western
Abstract
© 2021, The Author(s). Nutritional intake can promote early neonatal brain development in very preterm born neonates (\u3c 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p \u3c 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children
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Last time updated on 20/03/2021