CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Bioactive borophosphosilicate-polycaprolactone hybrid biomaterials: Via a non-aqueous sol gel process
Authors
Kibret Mequanint
Dibakar Mondal
Amin S. Rizkalla
Publication date
1 January 2016
Publisher
Scholarship@Western
Abstract
© 2016 The Royal Society of Chemistry. In this study, a non-aqueous sol-gel process was utilized to prepare novel class II hybrid biomaterials based on functionalized polycaprolactone (PCL) diol and borophosphosilicate glass (BPSG) as potential scaffold material for bone tissue engineering applications. PCL diol was first functionalized by reacting with (3-glycidoxypropyl)trimethoxysilane. The functionalized PCL (PCL-Si) was condensed with trimethyl borate, tetraethyl orthosilicate and triethyl phosphate via non-aqueous sol-gel reactions to form covalently bonded organic-inorganic networks. FTIR, TGA, XRD, and solid state 29Si CP-MAS NMR analyses revealed that the hybrid materials were successfully prepared. Furthermore, the hybrids were amorphous and transparent up to 60 wt% of PCL-Si content. Specifically, the organic-inorganic networks had a dominant T3 network since Si-C bond from PCL-Si is covalently bonded with the inorganic glass network and resulted in a class II hybrid. EDX and XPS studies showed uniform distribution of the various elements making up the hybrid materials. When incubated with simulated body fluids (SBF), the present hybrid materials were able to stimulate the deposition of crystalline hydroxyapatite. This study demonstrated, for the first time, the chemical reactivity of calcium-free BPSG and PCL-BPSG hybrids and their ability to deposit hydroxyapatite when incubated in SBF. The present study is also the first to incorporate B2O3 as a glass component in class II organic-inorganic hybrid biomaterials
Similar works
Full text
Available Versions
Scholarship@Western
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ir.lib.uwo.ca:boneandjoint...
Last time updated on 23/11/2020