CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Synthesis and properties of arborescent polyisobutylene derivatives and a paclitaxel conjugate: Towards stent coatings with prolonged drug release
Authors
Aneta Borecki
John R. De Bruyn
+4 more
Elizabeth R. Gillies
Mark Ingratta
Inderpreet Sran
John F. Trant
Publication date
1 November 2015
Publisher
Scholarship@Western
Abstract
© 2015 Elsevier Ltd. All rights reserved. Polyisobutylene (PIB) and its copolymers are used in a wide range of commercial products owing to their high chemical stability, impermeability, elasticity, and biocompatibility. The development of arborescent PIB (arb-PIB) opens many new possibilities for tuning PIB\u27s properties and for introducing new functionalities. In this work, arb-PIB with short isoprene-rich terminal sequences (arb-PIB-co-IP) was functionalized to provide arborescent epoxide, allylic alcohol, and carboxylic acid derivatives of PIB. The carboxylic acid derivative was used to conjugate the antiproliferative agent paclitaxel (PTX) for investigation as a potential vascular stent coating. The thermal, tensile, and rheological properties of all of the functionalized arb-PIB materials were studied and compared to their linear analogues in order to gain insight into the effects of polymer architecture on these properties as well as to determine their suitability as potential medical device coatings. A coating using the PTX conjugate was found to release PTX much more slowly than control formulations with physically encapsulated drug, yet was still able to prevent cell adhesion and proliferation on their surfaces
Similar works
Full text
Available Versions
Scholarship@Western
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ir.lib.uwo.ca:boneandjoint...
Last time updated on 23/11/2020