Alberto Corrias

Christof Markus Aegerter

Martin Lindsay Buist

Nicholas Cheng

Yong Cheng Poh

PLoS ONE

PubMed

Poh Yong Cheng

Corrias Alberto

Cheng Nicholas

Buist Martin Lindsay

Public Library of Science (PLOS)

A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated

Directory of Open Access Journals

A quantitative model of human jejunal smooth muscle cell electrophysiology.

Crossref

<div><p>Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.</p> </div

Yong Cheng Poh (142452)

Alberto Corrias (142454)

Nicholas Cheng (142455)

Martin Lindsay Buist (142458)

The Francis Crick Institute

A mathematical model of pacemaker activity recorded from mouse small intestine.

A mutation in telethonin alters Nav1.5 function.

A quantitative description of membrane current and its application to conduction and excitation in nerve.

A quantitative model of gastric smooth muscle cellular activation. Annals of biomedical engineering

A simple nonlinear model of electrical activity in the intestine.

Biophysically Based Mathematical Modeling of Interstitial Cells of Cajal Slow Wave Activity Generated from a Discrete Unitary Potential Basis. Biophysical journal 96:4834–4852.

Electrophysiology of Smooth-Muscle of the Small-Intestine of Some Mammals.

Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy. The American journal of gastroenterology 101:1299–1304.

Interstitial cells of Cajal as pacemakers in the gastrointestinal tract. Annual Review of Physiology 68:307–343.

Ionic conductances in gastrointestinal smooth muscles and interstitial cells of Cajal. Annual Review of Physiology 61:45–84.

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia.

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.

Numerical simulation of excitationcontraction coupling in a locus of the small bowel.

Numerical simulation of motility patterns of the small bowel. 1. formulation of a mathematical model.

Pump and Exchanger Mechanisms in a Model of Smooth-Muscle.

Quantitative cellular description of gastric slow wave activity. American journal of physiology. Gastrointestinal and liver physiology 294:G989–995.

Sodium channel mutation in the irritable bowel syndrome: Evidence for an ion channelopathy. American journal of physiology. Gastrointestinal and liver physiology.

Two components of potassium outward current in smooth muscle cells from the circular layer of human jejunum.

http://dx.doi.org/10.1371/journal.pone.0042385

A quantitative model of human jejunal smooth muscle cell electrophysiology

A quantitative model of human jejunal smooth muscle cell electrophysiology

Abstract

Similar works

Full text

Available Versions

Public Library of Science (PLOS)

Public Library of Science (PLOS)

Directory of Open Access Journals

Crossref

The Francis Crick Institute