The purpose of this 12-week pre-post design pilot study was to assess the impact of Motivational Interviewing via Co-Active Life Coaching (MI-via-CALC) on exercise-specific self-efficacy, barrier-specific self-efficacy, self-esteem, and 12-week study duration engagement in physical activity (PA) for 25 women between the ages of 30 and 55 years. Participants were assessed quantitatively using the previously validated McAuley Exercise-Specific Self-Efficacy Scale (EXSE), McAuley Barrier-Specific Self-Efficacy Scale (BARSE), Rosenberg Self-Esteem Scale (RSES), and International Physical Activity Questionnaire (IPAQ-SF) at pre-, mid-, and post-intervention. Four one-way repeated measures ANOVAs were completed for each scale, and statistically significant differences in barrier-specific self-efficacy were detected between pre- and post intervention, and statistically significant differences in self-esteem between pre- and post-intervention were found. No statistically significant differences were found in participants’ exercise-specific self-efficacy scores and IPAQ scores, although scores in both increased by the end of the study. Participants Body Mass Index (BMI), waist, and hip circumferences were also quantitatively measured at pre- and post-intervention. Paired t-tests were completed for each measure, and statistically significant decreases in weight, waist, and hip circumferences were detected. MI-via-CALC is an encouraging approach for women who are seeking a more physically active lifestyle, and additional research on a larger scale is recommended