A Mirsaidi

AR Lenox

B Cai

B Li

C Chen

CC Liu

D Tohyama

E Fathi

G Yang

H Ji

H Mobarak

H Sun

JF Mendes

JZ Guan

K Furumoto

KR Yu

L Chaouch

L He

L Jia

LH Lei

M Zhang

ME Carlson

PP Chothe

R Farahzadi

R Sangani

S Zhou

SC Huang

SL Gudmundsdottir

TP Devasagayam

TR Green

VC Broudy

W Zhang

XR Jiang

Y Chiba

Y He

Y Qi

YM Chang

Z Liu

Z Tang

AbstractThe aging of many mammalian tissues is associated with loss of functional adult stem cells, especially bone marrow-derived mesenchymal stem cells (BMSCs). This study was aimed to analyze the biological effect of chick embryo (CE) and nutrient mixture (NM) on the BMSCs of aging rats. The aging rat model was established to be induced by D-galactose (500 mg/kg/d) for 90 days. Meanwhile, aging rats were fed with CE and NM in different dose manner by intragastric administration. At the end of the experimental period, serum was collected from rats and used for BMSCs culture. Flow cytometric analysis was used to investigate the BMSCs surface markers. Alizarin Red and oil red O staining were performed to evaluate the multi-lineage differentiation of BMSCs. The results showed that CE plus NM increased the telomere length of BMSCs and promoted BMSCs proliferation. Moreover, CE plus NM administration promoted BMSCs differentiation into osteoblasts and suppressed differentiation into adipocytes. High-throughput sequencing analysis revealed that there were 326 genes were up-regulated and 59 genes were down-regulated in BMSCs of aging rats treated with CE plus NM. In conclusion, CE plus NM supplement had potential to delay aging through the recovery of BMSCs senescence and could be used as a safe effective approach for nutritional therapy of anti-aging.</jats:p

Jia Ma

Yanru Guo

Jialei Hu

Yue Pan

Xia Qi

Huaxin Wang

Li Jia

Crossref

Scientific Reports

The positive effect of chick embryo and nutrient mixture on bone marrow- derived mesenchymal stem cells from aging rats

The positive effect of chick embryo and nutrient mixture on bone marrow- derived mesenchymal stem cells from aging rats

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