•Worldwide hemorrhagic shock is the number one cause of death in trauma patients, the majority of those die from multi organ dysfunction syndrome [1, 2].
•During hemorrhagic shock (HS), the body undergoes global ischemia as blood pressure drops below the threshold at which
tissues can be adequately perfused with blood.
•Resistance to ischemic injury is a characteristic of hibernating mammals, including ground squirrels.
•There is debate on if this resistance is dependant on hibernation season or if it is an intrinsic plasticity of the organism.
QUESTION: Are AGS protected from HS‐induced ischemia reperfusion (I/R) injury on the whole organism and tissue–specific levels and if any protection is dependent upon their hibernation season.University of Alaska Fairbanks, Institute of Arctic Biology, Department of Chemistry and Biochemistr