Anup Roy

Chinmay Kumar Panda

Couch FJ

Cropp CS

Dutta V

Hemantika Dasgupta

Jaydip Biswas

Khokher S

Munjal K

Neyaz Alam

Nupur Mukherjee

Ochayon L

Parise CA

Reiner A

Rhiem K

Rittwika Bhattacharya

Saimul Islam

Sambrook J

Singh M

Susanta Roychoudhury

Yoshikawa K

 Aim: To understand the importance of homologous recombination repair pathway in development of breast carcinoma (BC), alterations of some key regulatory genes like BRCA1, BRCA2, FANCC and FANCD2 were analyzed in pretherapeutic/neoadjuvant chemotherapy (NACT)-treated BC samples. Materials &amp; methods: Alterations (deletion/methylation/expression) of the genes were analyzed in 118 pretherapeutic and 41 NACT-treated BC samples. Results: High deletion/methylation (29–68%) and 64–78% overall alterations of the genes were found in the samples. Concordance was evident between alteration and protein expression of the genes. Estrogen/progesterone receptor-negative tumors showed significantly high alterations even in NACT-treated samples having low CD44 and proliferating cell nuclear antigen expression. Pretherapeutic patients with alterations showed poor prognosis. Conclusion: Alterations of homologous recombination repair pathway genes are needed for the development of BC. </jats:p

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Future Oncology

Frequent alterations of homologous recombination repair pathway in primary and chemotolerant breast carcinomas: clinical importance

Frequent alterations of homologous recombination repair pathway in primary and chemotolerant breast carcinomas: clinical importance

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