Ankylosing spondylitis is a chronic rheumatic disease that affects the spine and sacroiliac joints, causing pain and inflammation. We presented a case of a 61 years old male with ankylosing spondylitis that, despite being receiving Nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics and prednisone showed clinical deterioration. The patient
received phototherapy within a range from 425 to 650 nm and a cytokine profile was measured at previous to the therapy and after 48 sessions. The clinical improvement was evident with pain remission and mobility recovery, as well as reduction in the proinflammatory cytokine profile
