Cheuka PM

Dong M

Douglas JD

Lechartier B

Les Baillie

Luis AJ Mur

Rafael Baptista

Robert J Nash

Santhosh RS

Slayden RA

Sumana Bhowmick

Verdine GL

 Tuberculosis is a major global health hazard. The search for new antimycobacterials has focused on such as screening combinational chemistry libraries or designing chemicals to target predefined pockets of essential bacterial proteins. The relative ineffectiveness of these has led to a reappraisal of natural products for new antimycobacterial drug leads. However, progress has been limited, we suggest through a failure in many cases to define the drug target and optimize the hits using this information. We highlight methods of target discovery needed to develop a drug into a candidate for clinical trials. We incorporate these into suggested analysis pipelines which could inform the research strategies to accelerate the development of new drug leads from natural products. </jats:p

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Future Medicinal Chemistry

Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products

Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products

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