Azadeh Haeri

Bozzuto G

Gerdes J

Granada JF

Guideline IHT

Habib A

Hanke H

Justice J

Maryam Sotoudeh Anvari

Pasut G

Saeed Sadeghian

Shahram Rabbani

Shapour Shirani

Simin Dadashzadeh

Tulis DA

 Aim: To develop an ameliorated sirolimus (SIR) liposome for intramural delivery, the effects of various carrier physicochemical parameters on the antirestenosis efficacy were evaluated. Materials &amp; methods: Different liposomes were prepared, characterized and administered to balloon injured rats (12 animal groups). Their efficacies were investigated using morphometric, immunohistochemical and in vivo computed tomography imaging analyses. Results: The antirestenosis efficacy of SIR liposomes decreased in the following order: cationic 100 nm vesicles ≥ cationic 60 nm vesicles &gt; neutral 100 nm vesicles ≥ stealth 100 nm vesicles &gt; anionic 100 nm vesicles. The 100 µg SIR loaded in cationic liposomes showed almost no artery stenosis. Conclusion: Appropriate modulation of physicochemical characteristics makes it possible to optimize the liposomes for local delivery. </jats:p

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Nanomedicine

Physicochemical characteristics of liposomes are decisive for their antirestenosis efficacy following local delivery

Physicochemical characteristics of liposomes are decisive for their antirestenosis efficacy following local delivery

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