Blann AD

Camoin-Jau L

Izabela Kubiszewska

Jacek Michałkiewicz

Joanna Banach

Katarzyna Buszko

Lehmann JM

Lidia Gackowska

Magdalena Grochowska

Robert Bujak

Wojciech Gilewski

Władysław Sinkiewicz

Łukasz Wołowiec

 Background: Melanoma cell adhesion molecule (MCAM) is a marker of endothelial damage. MCAM diagnostic and prognostic value was assessed in chronic heart failure (CHF). Materials &amp; methods: 130 CHF patients and 32 controls were included in the study. Telephone follow-up lasted one year. End points were: death from all causes, and hospitalization with CHF exacerbation. Results: MCAM was higher in patients than in controls (p = 0.01). Receiver operator curve analysis revealed that MCAM may serve as a predictor of death (area under the curve: 0.8404; p &lt; 0.002). Patients with MCAM above 500 ng/ml had worse prognosis (p = 0.03). NT-proBNP and age were independent predictors of death in multivariate analysis. Conclusion: The increased MCAM indicates endothelial damage in CHF and may serve as a marker of worse prognosis in these patients. </jats:p

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Biomarkers in Medicine

Melanoma cell adhesion molecule as an emerging biomarker with prognostic significance in systolic heart failure

Melanoma cell adhesion molecule as an emerging biomarker with prognostic significance in systolic heart failure

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