Abid, Shahab

Ahmad, Zubair

Butt, Amna Subhan

Hamid, Saeed

Jafri, Nida

Jafri, Wasim

Mumtaz, Khalid

Shah, Syed H

Yakoob, javed

English

eCommons@AKU

eCommons@AKUSection of Gastroenterology Department of MedicineApril 2008Analysis of Sustained Virological Response toPegylated Interferon & Ribavirin Treatment inCompensated Cirrhosis Due to Hepatitis C Virus,Genotype 3 InfectionAmna Subhan ButtAga Khan University, amna.subhan@aku.eduWasim JafriAga Khan University, wasim.jafri@aku.eduKhalid MumtazAga Khan University, khalid.mumtaz@aku.eduSaeed HamidAga Khan University, saeed.hamid@aku.eduShahab AbidAga Khan University, shahab.abid@aku.eduSee next page for additional authorsFollow this and additional works at: http://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterolPart of the Gastroenterology CommonsRecommended CitationButt, A., Jafri, W., Mumtaz, K., Hamid, S., Abid, S., Shah, S., Jafri, N., Yakoob, j., Ahmad, Z. (2008). Analysis of Sustained VirologicalResponse to Pegylated Interferon & Ribavirin Treatment in Compensated Cirrhosis Due to Hepatitis C Virus, Genotype 3 Infection.Gastroenterology, 134(4), A-832-A-832.Available at: http://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterol/146AuthorsAmna Subhan Butt, Wasim Jafri, Khalid Mumtaz, Saeed Hamid, Shahab Abid, Syed H Shah, Nida Jafri, javedYakoob, and Zubair AhmadThis article is available at eCommons@AKU: http://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterol/146AASLDAbstractsW1012Treatment of Hepatitis C Associated Severe Mixed CryoglobulinemicSyndrome with Plasma Exchange Improves Tolerability and Response toInterferon-Based TherapyTodd Frederick, Jamie Zagorski, Robert G. Gish, Jan C. HofmannIntroduction: Treatment of severe mixed cryoglobulinemic syndrome (MCS) associated withhepatitis C with interferon/ribavirin (IFN/RBV) is often difficult due to renal dysfunction,vasculitis, and neuropathy. Methods: We reviewed the medical records of 20 patients (pts)who were diagnosed with severe hepatitis C associated MCS and received interferon-basedtherapy and/or plasma exchange (PE). The mean age of pts was 54 years (46-63 years old)and 8 pts (40%) were male. 16 pts (80%) had HCV genotype 1A or 1B. 13 pts (65%) hadelevated HCV RNA (>400,000 IU/ml) and 11 pts (55%) had cirrhosis or advanced fibrosis.Clinical Presentation: 17 pts (85%) presented with renal disease. 12 pts (60%) had chronicrenal insufficiency, and 5 pts (25%) presented with acute renal failure requiring hemodialysis(HD). 17 pts (85%) had elevated 24-hour urine protein; 13 pts had nephrotic range pro-teinuria. 13 pts (65%) presented with active vasculitic skin lesions. 7 pts (35%) had peripheralneuropathy. 1 pt had severe CNS and pulmonary vasculitis. Treatment: Of 20 pts whoreceived PE treatment, 16 pts (80%) were candidates to start (or reinstitute) IFN/RBV therapy(intent-to-treat [ITT] group). 11 of these pts successfully started Peg 2a/b IFN therapy, and10 pts started RBV. 4 pts (20%) were not IFN/RBV candidates because of prior SVR or IFN/RBV failure. The mean number of inpatient PE treatments (txs) was 8.6 (5-12 txs). 8 pts(40%) received cyclophosphamide; 5 pts (25%) received rituximab (4-6 doses). 6 pts (30%)required chronic PE txs (2-8X/month). Results: 18 pts (90%) experienced clinical improve-ment after initial course of intensive PE therapy. Of 13 pts with nephrotic range proteinuria,9 pts (69%) had significant decline in urinary protein. 3 of 5 pts (60%) on HD were ableto stop dialysis. 12 pts (92%) demonstrated significant improvement in vasculitic skinlesions. 5 pts (71%) had slight improvement in peripheral neuropathy. Of 11 pts whoreceived IFN/RBV post-PE (ITT success), 3 pts had SVR, 3 pts were NR, 4 pts have ongoingtreatment (2 pts are HCV RNA neg., 2 are HCV RNA pos.), and 1 pt died but had EVR.The pts with SVR had marked improvement in MCS symptoms, whereas the NR pts allrequired chronic PE for refractory disease. Of 5 pts who did not receive IFN/RBV post-PE(ITT failure), 3 pts died (2 of complications of MCS) before starting IFN/RBV, 1 pt underwenttransplantation, and 1 pt was not clinically stable for antiviral therapy. Conclusion: Treatmentof hepatitis C associated severe mixed cryoglobulinemic syndrome with plasma exchangeappears to improve tolerability and response to interferon-based therapy.W1013Feasibility of Interferon-Beta Induction By Twice-Daily Administration Prior tothe Standard Combination Therapy Using Pegylated Interferon-Alpha-2b PlusRibavirinToshiya Nakatani, Eri Satani, Shinya Takeyama, Sanae Murata, Shinsaku Nagamatsu, KojiHashimoto, Hideki Matsuo, Eiryo KikuchiAims: It has been reported that longer treatment with combination therapy using pegylatedinterferon (IFN)-alpha-2b plus ribavirin (RIB) for patients infected with hepatitis C virus(HCV) leads to more effective viral eradication. However, in Japan where treatment periodis limited, the achievement of early viral clearance should be necessary. We already reportedthe effectiveness of IFN-beta induction prior to the standard 48-week combination therapyin achieving early viral response (EVR). In this study, it is evaluated whether IFN-betainduction is also effective in achieving sustained viral response (SVR). Methods: Sixty-twopatients chronically infected with genotype 1b HCV were divided into 2 groups. Forty-twopatients underwent standard 48-week combination therapy using 1.5µg/kg of pegylatedIFN-alpha-2b plus RIB (600-1000 mg/day depending on body weight) (group1). Twentypatients received 3MU IFN-beta twice-daily for 2 weeks, followed by the standard combina-tion therapy described above (group2). HCV quantity as well as its reduction profile suchas HCV negativity and rate of 2-log decrease was assessed at the certain time point. SerumHCV-RNA was quantified using the Amplicor HCV monitor assay (SRL, Tokyo, Japan). EVRdefined as HCV-RNA negative at weeks 12 in the 48-week therapeutic period tends to bereferred to as one of the predictive landmarks for the subsequent SVR. We evaluated theeffectiveness of IFN-beta induction by assessing EVR as well as SVR. Results: HCV quantityof each patient was more than 100 KIU/mL, meaning the high baseline viral load. Gender,age, platelet and ALT at baseline did not differ significantly between 2 groups. Serum HCV-RNA (KIU/mL) at baseline, weeks 2, 4, 8, 12, 16, 24 and 48 was 2248±1593/3197±1716(P<0.05), 237±257/52±107 (P<0.05), 157±199/56±147, 107±176/16±59 (P<0.05), 79±155/0.2±0.3 (P<0.05), 69±148/14±58 (P<0.05) and 40±122/0±0 in group1 and group2, respect-ively. HCV negativity at weeks 2, 4, 8, 12, 20 and 28 was 0%/0%, 2.5%/15.8%, 17.9%/33.3%, 30.8%/87.5% (EVR; P<0.05), 44.1%/87.5% (P<0.05) and 63.3%/100% (P<0.05) ingroup1 and group2, respectively. SVR rate was 87.5%/47.9% (P<0.05) in group1 and group2,respectively. In the multivariate analysis, the factor of ‘IFN-beta induction‘ was significantlyand independently associated with EVR, and that of ‘EVR achievement‘ was associated withSVR. Conclusion: When the length of combination therapy using pegylated IFN-alpha-2bplus RIB is limited to 48 weeks, IFN-beta induction may be feasible in achieving SVRthroughout successful achievement of EVR.W1014Treatment After Liver Biopsy in Patients with Hepatitis C Virus (HCV) andHIV Co-InfectionKavitha Gopal, Pauline Suwandhi, Arkady Broder, Henry C. Bodenheimer, Albert D. MinHighly active antiretroviral therapy for HIV infection has decreased HIV-related mortality.However, due to accelerated progression of liver fibrosis and decompensation in HCV / HIVco-infected patients, the incidence of liver-related mortality has risen significantly. The aimof our study was to evaluate the number of liver biopsies in HCV / HIV co-infected patientsand the influence on treatment decision. Method: We reviewed charts of patients with HCV/HIV co-infection who had a liver biopsy from 1/1998 to 10/2007, who have been followedT : 11501$$CH304-02-08 17:16:46 Page 832Layout: 11501B : eA-832AASLD Abstractsat our medical center. Results: Among the 238 patients with HCV / HIV co-infection seenduring this study period, 152 (64%) had liver biopsy. Patients were predominantly male(116; 77%), and mean age at biopsy was 47.8 years (range 31-66). Majority of the patientswere infected with genotype 1 (123; 81%). History of intravenous drug use and heavyalcohol consumption were documented in 104 (68%) and 32 (21%) patients, respectively.Fifty-three (35%), 82 (54%) and 13 (9%) patients had stage 0-1, 2-3, and 4 fibrosis,respectively. Stage was indeterminate in 3 (2%) patients. The number of liver biopsies andthe rate of subsequent HCV treatment are shown in the figures 1 and 2. Fifty-seven of 152(38%) patients were started on HCV treatment. Common reasons for not starting treatmentafter liver biopsy were patients lost to follow up in 26 (27%), minimal liver disease onbiopsy in 20 (21%) and patients refusal in 17 (18%). Conclusions: The number of co-infected patients evaluated for treatment with a liver biopsy has decreased over past fewyears possibly due to a low threshold to start treatment in the co-infected patient. Low post-biopsy treatment rates with 21% of patients showing favorable histology, suggests thatliver biopsy remains a useful tool in directing management in selected HIV / HCV co-infected patients.W1015Analysis of Sustained Virological Response to Pegylated Interferon &Ribavirin Treatment in Compensated Cirrhosis Due to Hepatitis C Virus,Genotype 3 InfectionAmna Subhan, Wasim Jafri, Khalid Mumtaz, Saeed S. Hamid, Shahab Abid, HasnainShah, Nida Jafri, Javed Yakoob, Zubair AhmedBACK GROUND: Chronic hepatitis C virus (HCV) infection in patients with cirrhosis isdifficult to treat and data on the outcome of treatment for this patient group is limited.AIMS: To study sustained virologic response (SVR) & its predictive factors in patients withcompensated cirrhosis due to hepatitis C, treated with pegylated interferon & ribavirin.METHODS: Data of patients with compensated cirrhosis due to HCV genotype 3 withpositive HCV RNA PCR was collected from our Gastroenterology clinic database during2004 to 2006. Cirrhosis was diagnosed either by liver biopsy or on biochemical testing withultrasound of abdomen. Primary end point of treatment was SVR. Treatment was terminatedor modified in case of hepatic decompensation or if hemoglobin dropped to < 7.0 gm /dl,absolute neutrophil count (ANC) <1000 x10E 9, platelets <50,000/cmm. We also evaluatedthe predictors of outcomes of SVR. RESULTS: Out of 66 patients, 32(48.5%) were male.Mean age was 46± 10. 34/66 (51.5%) patients were non-naive. There were 61(92.4%)patients with Child's A cirrhosis followed by 5(7.6%) with child B. 33 (50%) patientsreceived pegylated interferon alfa-2a (180mcg/wk) with ribavirin and 33(50%) receivedpegylated interferon alfa 2b (1-1.5mcg/kg/week) along with ribavirin. There were 46 (67.7%)patients who received treatment for 6 months and other 15 (22.7%) for 12 months, as theywere unable to achieve EVR at 3 months and/or clear the virus at 6 months. EVR wasachieved in 43(65.1%), and ETR in 49(74.24%); overall SVR was achieved in 38 (57.6%)patients. Factors predictive of SVR were age <35 years (p=0.01), treatment naïve status (p=0.04), EVR (p=<0.01). Five patients were unable to complete the treatment due to sideeffects or cytopenias not responding to erythropoietin and or G-CSF therapy. Conclusions:Treatment of HCV genotype 3 patients with compensated cirrhosis with pegylated interferonand ribavirin is effective and toleratable though supportive treatment with erythropoietinand G-CSF required in some cases. Keywords: hepatitis C, pegylated interferon, compens-ated cirrhosisW1016Efficacy and Safety of Erythropoietin-Alfa On NaïVe Patients with ChronicHepatitis C and Genotype 1 Receiving Combination Therapy with PegylatedInterferon-Alfa 2b and RibavirinDagmary Purcell, Doris H. ToroBackground:Treatment of hepatitis c virus (HCV) infection with peg-interferon and ribavarinresults in sustained viral response(SVR) in 42-46% of the patients with genotype 1.Weightbased ribavarin in these subset of patients has been shown to increase the SVR.Erythropoietin

Analysis of Sustained Virological Response to Pegylated Interferon & Ribavirin Treatment in Compensated Cirrhosis Due to Hepatitis C Virus, Genotype 3 Infection

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Analysis of Sustained Virological Response to Pegylated Interferon & Ribavirin Treatment in Compensated Cirrhosis Due to Hepatitis C Virus, Genotype 3 Infection

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