The notion that climate change may impact coastal fish production suggests a need to understand how climatic variables may influence fish catches at different time scales. Evidence suggests that the effect of climatic variability and fishing effort on landed catches (as proxy of fish abundance) may vary at the regional scale. This study aims to assess the sensibility of two commercial species with a short life cycle (Engraulis encrasicolus and Sepia officinalis) to climatic and fisheries effects across different regions of the coast of Portugal: northwestern, southwestern and southern Portugal. The effect of environmental explanatory variables, i.e. NAO index, sea surface temperature (SST), upwelling (UPW) index, river discharge, wind magnitude (WmaG), wind direction (Wdir), and fishing variables (fishing effort) on catch rates time series were studied between 1989 and 2009. The sensibility of the species studied to climatic variability differed among regions and were explained by different climatic variables. River discharge had a significant effect on catch rates of the two species, region independently. However, wind driven phenomenon and UPW were the variables that better explained the observed fishing trends across the three regions. Changes in catch rate trends among the studied regions, at a given time, were mostly associated with the reproduction periods of the species. Therefore, regional analyses will significantly contribute to a better understanding of the relationship between climate change and coastal fisheries, aiming to improve integrated coastal zone management