Baibek, Assel

Bradley, Mark

Clavadetscher, Jessica

Gambardella, Alessia

Geng, Jin

Lilienkampf, Annamaria

Litzen, Inga

Zhang, Shuo

Zhang, Yichuan

Üçüncü, Muhammed

English

With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional groups on the dendrimers exponentially amplified intensities of fluorescent markers in antibody-targeted live cell imaging. This novel "swarming"approach highlights the power of bioorthogonal chemistry and provides a route to non-natural chemical structures on cells, paving the way for the generation of various artificial cellular nanostructures and scaffolds. </p

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Bioorthogonal Swarming: In Situ Generation of Dendrimers

https://www.research.ed.ac.uk/files/191093039/20210117_Lilienkampf_Swarming_JACS_revised_final.pdf

Bioorthogonal Swarming: In Situ Generation of Dendrimers

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