Abrahams, Sharon

Aho-Özhan, Helena E. A.

Bauer, Lisa

Böhm, Sarah

Gorges, Martin

Kassubek, Jan

Keller, Jürgen

Krimly, Amon

Ludolph, Albert C

Lulé, Dorothée

Pinkhardt, Elmar H.

Schulenburg, Sarah

Uttner, Ingo

English

Objective: Reliable assessment of cognitive functions is a challenging task in amyotrophic lateral sclerosis (ALS) patients unable to speak and write. We therefore present an eye-tracking based neuropsychological screening tool based on the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), a standard screening tool for cognitive deficits in ALS. Methods: In total, 46 ALS patients and 50 healthy controls matched for age, gender and education were tested with an oculomotor based and a standard paper-and-pencil version of the ECAS. Results: Significant correlation between both versions was observed for ALS patients and healthy controls in the ECAS total score and in all of its ALS-specific domains (all r &gt; 0.3; all p &lt; 0.05). The eye-tracking version of the ECAS reliably distinguished between ALS patients and healthy controls in the ECAS total score (p &lt; 0.05). Also, cognitively impaired and non-impaired patients could be reliably distinguished with a specificity of 95%. Conclusion: This study provides first evidence that the eye-tracking based ECAS version is a promising approach for assessing cognitive deficits in ALS patients who are unable to speak or write

Edinburgh Research Explorer

A first approach to a neuropsychological screening tool using eye-tracking for bedside cognitive testing based on the Edinburgh Cognitive and Behavioural ALS Screen

Jürgen Keller

Amon Krimly

Lisa Bauer

Sarah Schulenburg

Sarah Böhm

Helena E. A. Aho-Özhan

Ingo Uttner

Martin Gorges

Jan Kassubek

Elmar H. Pinkhardt

Sharon Abrahams

Albert C. Ludolph

Dorothée Lulé

Crossref

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

https://www.research.ed.ac.uk/files/33545854/KellerEtalALSFD2017AFirstApproachToANeuropsychological.pdf

A first approach to a neuropsychological screening tool using eye-tracking for bedside cognitive testing based on the Edinburgh Cognitive and Behavioural ALS Screen

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