Aberle

Asner

Brand

Bénet

Calvo

Caracciolo

da Silva

DaPalma

De Paulis

Egger

Escobar

Espínola

Falkenstein-Hagander

Foulongne

Friede

Frobert

Gagliardi

Goka

Gokce

Hament

Janahi

Kelly

Kwon

Mansbach

Marguet

Matsuno

Mazur

Mação

Moher

Petrarca

Pneumonia Etiology Research for Child Health (PERCH) Study Group

Richard

Scotta

Semple

Tran

Venter

Wang

English

Crossref

The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): A systematic review and meta-analysis

Background Respiratory syncytial virus (RSV) is the predominant viral cause of childhood pneumonia. Little is known about the role of viral-coinfections in the clinical severity in children infected with RSV. Methods We conducted a systematic literature review of publications comparing the clinical severity between RSV mono-infection and RSV co-infection with other viruses in children under five years (&lt;5y). Clinical severity was measured using the following six clinical outcomes: hospitalisation, length of hospital stay, use of supplemental oxygen, intensive care unit (ICU) admission, mechanical ventilation and deaths. We summarised the findings by clinical outcome and conducted random-effect meta-analyses, where applicable, to quantitatively synthesize the association between RSV mono-infection/RSV co-infection and the clinical severity. Results Overall, no differences in the clinical severity were found between RSV mono-infection and RSV co-infection with any viruses, except for the RSV-human metapneumovirus (hMPV) co-infection. RSV-hMPV coinfection was found to be associated with a higher risk of ICU admission (odds ratio [OR]: 7.2, 95% confidence interval [CI]: 2.1–25.1; OR after removal of the most influential study: 3.7, 95% CI: 1.1–12.3). We also observed a trend from three studies that RSV-hMPV coinfections were likely to be associated with longer hospital stay. Conclusion Our findings suggest that RSV-hMPV coinfections might be associated with increased risk for ICU admission in children &lt;5y compared with RSV mono-infection but such association does not imply causation. Our findings do not support the association between RSV coinfections with other viruses and clinical severity but further large-scale investigations are needed to confirm the findings

Li, You

Pillai, Pallavi

Miyake, Fuyu

Nair, Harish

Edinburgh Research Explorer

The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV)::a systematic review and meta-analysis

https://www.research.ed.ac.uk/portal/files/147471402/The_role_of_viral_co_infections.pdf

The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV)::a systematic review and meta-analysis

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Edinburgh Research Explorer