Bermingham, M.

Berry, D.

Cromie, A.

Good, M.

Higgens, I.

More, S.

Edinburgh Research Explorer

     Edinburgh Research Explorer                                      Genetic correlations between susceptibility to  Mycobacteriumbovis  infection   and performance in Irish Holstein Friesian dairycowsCitation for published version:Bermingham, M, More, S, Good, M, Cromie, A, Higgens, I & Berry, D 2010, 'Genetic correlations betweensusceptibility to  Mycobacterium bovis  infection   and performance in Irish Holstein Friesian dairy cows',Leipzig, 1/08/10 - 6/08/10, pp. paper 766.Link:Link to publication record in Edinburgh Research ExplorerDocument Version:Early version, also known as pre-printGeneral rightsCopyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s)and / or other copyright owners and it is a condition of accessing these publications that users recognise andabide by the legal requirements associated with these rights.Take down policyThe University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorercontent complies with UK legislation. If you believe that the public display of this file breaches copyright pleasecontact openaccess@ed.ac.uk providing details, and we will remove access to the work immediately andinvestigate your claim.Download date: 05. Apr. 2019Genetic correlations betweensusceptibility to Mycobacterium bovis infectionand performancein Irish Holstein Friesian dairy cowsM.L. Bermingham, S.J. More, M. Good,A.R. Cromie, I. M. Higgins and D.P. BerryBovine tuberculosis (bTB)• Infectious respiratory disease• wide range of animals• including man• tubercles (granuloma)Mycobacteria bovis• The primary agent of bTBIntroductionActive surveillance• Single intradermal comparative tuberculin test (SICTT)M. bovis purified protein derivative - MboPPDM. avium purified protein derivative - MavPPDMboPPDMavPPD- Annually in Republicof Ireland (ROI)IntroductionSICTT InterpretationStandard InterpretationMboPPDMavPPDIntroductionNon bTB-free status• Ireland/other countries• Transmission- wildlife-to-cattle- cattle-to-cattleIntroductionGenetic selection•↑ resistance to bTB in cattle• complement eradication effortsBermingham et al. 2009Brotherstone et al. 20100.18 (0.041)0.18 (0.044)Abattoir-confirmed M. bovis infection0.14 (0.025)0.16 (0.012)Responsiveness to the SICTTROI dataGB dataHeritabilities:Two recent studies- Exploitable variation exists among GB and ROI HF dairycows for resistance to tuberculosisGenetic correlation ~1.0- ROI dairy cows-↑ resistance to confirmed M. bovis infection- via SICTT dataIntroductionGenetic correlations• -ve: susceptibility to confirmed M. bovis infectionvs. milk yield (UK)• antagonistic: risk of clinical mastitisvs. milk yield• inconsistent: susceptibility to other diseasesvs. performanceImpact of selection of economically important traits- Genetic resistance to M. bovis infection- ROI dairy cattle needs to be determinedIntroduction• To estimate the genetic correlations betweensusceptibility to M. bovis infection andeconomically important traitsObjectiveMeasure of bovine susceptibility M. bovis infectionMaterials and MethodsMaterials and MethodsEight performance traits• Milk yield• Fat yield• Protein yield• Somatic cell score• Calving interval• Survival• Body condition scoreData• 108,000 SICTT herd summary records• 2,000,000 SICTT results• November 2000 to December 2007Data Edits• Episodes- High likelihood of exposure to M. bovis- SICTT herd summary records→ divide dataSICTT responsivenessEpisodeSICTT responsivenessData Edits• Deleted animals- No known pedigree data- Outside the normal age for a given parity- Inconclusive SICTT results- Moved into the herd - 6 weeks of SICTT• Retained episodes- 1 standard reactor- 10 or more animalsSICTT responsivenessData records• 17,178 SICTT responsiveness• 598 episodesData• 3,600,000 305-day milk, fat & protein yield & SCC• 6,500,000 calving date and calving interval (CI)• 86,000 1st parity body condition score (BCS)- Irish cattle breeding federation database- calvings January 1985 to December 2007Performance traitsData Edits• Cow survival lactation 1-2, 2-3 & 3-4• Deleted Cows- CIs < 300 > 800 days- Unknown parity- <15 months of age- Outside the normal age for a given parity- <75% Holstein-Friesian- No known sirePerformance traitsData records• 105,064 production- 2,185 M. bovis infection records• 112,337 CI- 2,389 M. bovis infection records• 104,044 survival- 2,895 M. bovis infection records• 57,250 BCS- 354 M. bovis infection recordsGenetic & residual (co) variance components• Responsiveness to the SICTTvs. performance- bivariate linear-linear sire model- bivariate threshold-linear sire models• Statistical package ASREML• Significance: Likelihood ratio testAnalysis0.36 (0.14)BCS-0.62 (0.22)-0.17 (0.23)-0.08 (0.22)Survival-0.18 (0.29)0.00 (0.22)-0.07 (0.18)CI-0.14 (0.17)0.11 (0.15)-0.34 (0.14)SCS0.06 (0.16)0.32 (0.14)0.16 (0.15)Protein0.23 (0.15)0.39 (0.13)0.32 (0.14)Fat0.13 (0.16)0.24 (0.14)0.23 (0.14)MilkParity 3Parity 2Parity 1Responsiveness to the SICTTTraitSignificance of the difference from zero; P < 0.05ResultsResultsThe test of significance: t-test; P> 0.05TLMLLM0.35 (0.13)0.36 (0.14)BCS-0.67 (0.21)-0.62 (0.22)Survival-0.29 (0.14)-0.34 (0.14)SCS0.37 (0.13)0.39 (0.13)FatResponsiveness to the SICTTTraitDiscussion• Results from this study- Based on→ large datasets→ alternative statistical approaches- Selection for→↑ survival may indirectly↓→↓ SCS &↑ fat production & BCS•↑ susceptibility to M. bovis infection• ROI Holstein Friesian dairy herdAcknowledgementsFinancial support from ERAD and BBSRC is gratefully acknowledged

Genetic correlations between susceptibility to Mycobacterium bovis infection and performance in Irish Holstein Friesian dairy cows

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Genetic correlations between susceptibility to Mycobacterium bovis infection and performance in Irish Holstein Friesian dairy cows

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