Achenbach

Andreasen

Andrew C. Stanfield

Andrew G. McKechanie

David G. C. Owens

Duvernoy

Eve C. Johnstone

Goldberg

Harding

Heather C. Whalley

Katschnig

Quitkin

Stephen M. Lawrie

Talairach

Thomas W. J. Moorhead

BackgroundNegative symptoms are perhaps the most disabling feature of schizophrenia. Their pathogenesis remains poorly understood and it has been difficult to assess their development over time with imaging techniques.AimsTo examine, using tensor-based structural imaging techniques, whether there are regions of progressive gray matter volume change associated with the development of negative symptoms.Method43 adolescents at risk of psychosis were examined using magnetic resonance imaging and whole-brain tensor-based morphometry at two time points, 6 years apart.ResultsWhen comparing the individuals with significant negative symptoms with the remaining participants, we identified 5 regions of significant gray matter tissue loss over the 6-year period. These regions included the left temporal lobe, the left cerebellum, the left posterior cingulate and the left inferior parietal sulcus. ConclusionsNegative symptoms are associated with longitudinal gray matter tissue loss. The regions identified include areas associated with all psychotic symptoms, but also include regions uniquely associated negative symptoms.<br/

McKechanie, Andrew

Moorhead, T. William J.

Stanfield, Andrew C.

Whalley, Heather C.

Johnstone, Eve

Lawrie, Stephen M.

Owens, David G. C.

Edinburgh Research Explorer

Negative symptoms and longitudinal gray matter tissue loss in adolescents at risk of psychosis:Preliminary findings from a 6-year follow-up study.

BackgroundNegative symptoms are perhaps the most disabling feature of schizophrenia. Their pathogenesis remains poorly understood and it has been difficult to assess their development over time with imaging techniques.AimsTo examine, using tensor-based structural imaging techniques, whether there are regions of progressive grey matter volume change associated with the development of negative symptoms.MethodA total of 43 adolescents at risk of psychosis were examined using magnetic resonance imaging and whole brain tensor-based morphometry at two time points, 6 years apart.ResultsWhen comparing the individuals with significant negative symptoms with the remaining participants, we identified five regions of significant grey matter tissue loss over the 6-year period. These regions included the left temporal lobe, the left cerebellum, the left posterior cingulate and the left inferior parietal sulcus.ConclusionsNegative symptoms are associated with longitudinal grey matter tissue loss. The regions identified include areas associated with psychotic symptoms more generally but also include regions uniquely associated with negative symptoms.</jats:sec

Crossref

The British Journal of Psychiatry

Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: Preliminary findings from a 6-year follow-up study

https://www.pure.ed.ac.uk/ws/files/22274415/McKechanie_Negative_Symptoms_Manuscript_PURE.pdf

Negative symptoms and longitudinal gray matter tissue loss in adolescents at risk of psychosis:Preliminary findings from a 6-year follow-up study.

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