Abrahams, Sharon

Della Sala, Sergio

Fabi, K.

Logie, Robert

Luzzi, S.

Parra, Mario

English

Fabi, Katia

Parra, Mario A.

Luzzi, Simona

University of Strathclyde Institutional Repository

Fabi, Katia and Parra, Mario A. and Abrahams, Sharon and Luzzi, Simona and Della Sala, Sergio (2009) Short-term memory binding in Alzheimer's Disease and other non-Alzheimer dementias. In: XL Congress of the Italian Neurological Society, 2009-11-01 - 2009-11-01. , This version is available at https://strathprints.strath.ac.uk/66025/Strathprints is  designed  to  allow  users  to  access  the  research  output  of  the  University  of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may  not  engage  in  further  distribution  of  the  material  for  any  profitmaking  activities  or  any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge. Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output.© Fabi, K., Parra, M., Abrahams, S., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short-term memory binding in Alzheimers Disease and other non-Alzheimer dementia. Poster session presented at XL Congress of the Italian Neurological Society, Padova, Italy.  Short-term memory binding in Alzheimer’s disease and other non-Alzheimer dementias  Katia Fabi a, Mario A. Parra b, Sharon Abrahams b, Simona Luzzi a, Sergio Della Sala b  a: Section of Clinical Neurology, Polytechnic University of Marche, Ancona, Italy b: Human Cognitive Neuroscience, Psychology, The University of Edinburgh, UK  Abstract  Background: Temporary memory for objects bound with colours is impaired in patients with Alzheimer’s disease (AD) (Parra et al., 2009). However, temporary memory for coloured items is not affected by age (Brockmole et al., 2008; Parra et al., 2009). How specific is this STM binding impairment in AD, remains unknown. Aims:  To investigate STM binding in AD and non-AD dementias. Methods: A STM binding task was devised requesting participants to remember arrays of common objects, colours, objects and colours as independent features (unbound), or objects bound with colours. Participants’ free recall of the studied items was assessed immediately after a brief presentation. Patients with AD (n = 15), Fronto-Temporal Dementia (n = 14), Parkinson Dementia (n = 10) and Vascular Dementia (n = 9) matched for demographic and neuropsychological background, and an age and education matched sample of healthy older adults (n = 21) entered the study. All patients were assessed with 4 single, 4 unbound items or 2 bound items, whereas healthy elderly with 8 single, 8 unbound items or 4 bound items. Results: a two-way mixed ANOVA revealed significant effects of Group and an interaction between Group and Stimuli (i.e., single vs. unbound vs. bound items). The interaction was solely driven by AD patients performing worse than the other groups in the binding condition only. Performance in the binding condition was dramatically worse than in the single and unbound items conditions only in AD patients. Conclusions: STM binding is affected in AD patients but is spared in healthy older adults and non-AD dementias. This suggests that STM binding deficits are specific to AD.  Brockmole, J., Parra, M.A., Della Sala, S., & Logie, R. (2008). Do Binding Deficits Account for Age-Related Decline in Visual Working Memory? Psychonomic Bulletin & Review, 15, 543-547.  Parra, M.A., Abrahams, S., Logie, R., & Della Sala, S., (2009). Age and binding within-dimension features in visual short term memory. Neuroscience Letters, 449, 1-5.  Parra, M.A., Abrahams, S., Fabi, K., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short term memory binding deficits in Alzheimer’s Disease. Brain, 132, 1057–1066.  SIN Congress - 2009 

Short-term memory binding in Alzheimer's Disease and other non-Alzheimer dementias

Parra Rodriguez, Mario

Logie, Robert H.

Heriot Watt Pure

Short-term memory binding in Alzheimer's disease and other non-Alzheimer dementia

Short-term memory binding in Alzheimer's Disease and other non-Alzheimer dementia

Edinburgh Research Explorer

     Edinburgh Research Explorer                                      Short-term memory binding in Alzheimer’s Disease and othernon-Alzheimer dementia.Citation for published version:Parra, M, Fabi, K, Abrahams, S, Logie, R, Luzzi, S & Della Sala, S 2010, 'Short-term memory binding inAlzheimer’s Disease and other non-Alzheimer dementia.' 2nd Meeting of the Federation of EuropeanSocieties of Neuropsychology, Amsterdam, Netherlands, 22/09/10 - 24/09/10, .Link:Link to publication record in Edinburgh Research ExplorerDocument Version:Author final version (often known as postprint)Publisher Rights Statement:© Parra, M., Fabi, K., Abrahams, S., Logie, R., Luzzi, S., & Della Sala, S. (2010). Short-term memory binding inAlzheimer’s Disease and other non-Alzheimer dementia.. Poster session presented at 2nd Meeting of theFederation of European Societies of Neuropsychology, Amsterdam, Netherlands.General rightsCopyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s)and / or other copyright owners and it is a condition of accessing these publications that users recognise andabide by the legal requirements associated with these rights.Take down policyThe University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorercontent complies with UK legislation. If you believe that the public display of this file breaches copyright pleasecontact openaccess@ed.ac.uk providing details, and we will remove access to the work immediately andinvestigate your claim.Download date: 20. Feb. 2015© Fabi, K., Parra, M., Abrahams, S., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short-term memory binding in Alzheimer’s Disease and other non-Alzheimer dementia. Poster session presented at XL Congress of the Italian Neurological Society, Padova, Italy.  Short-term memory binding in Alzheimer’s disease and other non-Alzheimer dementias  Katia Fabi a, Mario A. Parra b, Sharon Abrahams b, Simona Luzzi a, Sergio Della Sala b  a: Section of Clinical Neurology, Polytechnic University of Marche, Ancona, Italy b: Human Cognitive Neuroscience, Psychology, The University of Edinburgh, UK  Abstract  Background: Temporary memory for objects bound with colours is impaired in patients with Alzheimer’s disease (AD) (Parra et al., 2009). However, temporary memory for coloured items is not affected by age (Brockmole et al., 2008; Parra et al., 2009). How specific is this STM binding impairment in AD, remains unknown. Aims:  To investigate STM binding in AD and non-AD dementias. Methods: A STM binding task was devised requesting participants to remember arrays of common objects, colours, objects and colours as independent features (unbound), or objects bound with colours. Participants’ free recall of the studied items was assessed immediately after a brief presentation. Patients with AD (n = 15), Fronto-Temporal Dementia (n = 14), Parkinson Dementia (n = 10) and Vascular Dementia (n = 9) matched for demographic and neuropsychological background, and an age and education matched sample of healthy older adults (n = 21) entered the study. All patients were assessed with 4 single, 4 unbound items or 2 bound items, whereas healthy elderly with 8 single, 8 unbound items or 4 bound items. Results: a two-way mixed ANOVA revealed significant effects of Group and an interaction between Group and Stimuli (i.e., single vs. unbound vs. bound items). The interaction was solely driven by AD patients performing worse than the other groups in the binding condition only. Performance in the binding condition was dramatically worse than in the single and unbound items conditions only in AD patients. Conclusions: STM binding is affected in AD patients but is spared in healthy older adults and non-AD dementias. This suggests that STM binding deficits are specific to AD.  Brockmole, J., Parra, M.A., Della Sala, S., & Logie, R. (2008). Do Binding Deficits Account for Age-Related Decline in Visual Working Memory? Psychonomic Bulletin & Review, 15, 543-547.  Parra, M.A., Abrahams, S., Logie, R., & Della Sala, S., (2009). Age and binding within-dimension features in visual short term memory. Neuroscience Letters, 449, 1-5.  Parra, M.A., Abrahams, S., Fabi, K., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short term memory binding deficits in Alzheimer’s Disease. Brain, 132, 1057–1066.  SIN Congress - 2009 

Short-term memory binding in Alzheimer’s Disease and other non-Alzheimer dementia.

     Edinburgh Research Explorer                                      Short-term memory binding in Alzheimer’s Disease and othernon-Alzheimer dementiaCitation for published version:Fabi, K, Parra, M, Abrahams, S, Logie, R, Luzzi, S & Della Sala, S 2009, 'Short-term memory binding inAlzheimer’s Disease and other non-Alzheimer dementia' XL Congress of the Italian Neurological Society,Padova, Italy, 1/11/09 - 1/11/09, .Link:Link to publication record in Edinburgh Research ExplorerDocument Version:Author final version (often known as postprint)Publisher Rights Statement:© Fabi, K., Parra, M., Abrahams, S., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short-term memory binding inAlzheimer’s Disease and other non-Alzheimer dementia. Poster session presented at XL Congress of the ItalianNeurological Society, Padova, Italy.General rightsCopyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s)and / or other copyright owners and it is a condition of accessing these publications that users recognise andabide by the legal requirements associated with these rights.Take down policyThe University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorercontent complies with UK legislation. If you believe that the public display of this file breaches copyright pleasecontact openaccess@ed.ac.uk providing details, and we will remove access to the work immediately andinvestigate your claim.Download date: 20. Feb. 2015© Fabi, K., Parra, M., Abrahams, S., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short-term memory binding in Alzheimer’s Disease and other non-Alzheimer dementia. Poster session presented at XL Congress of the Italian Neurological Society, Padova, Italy.  Short-term memory binding in Alzheimer’s disease and other non-Alzheimer dementias  Katia Fabi a, Mario A. Parra b, Sharon Abrahams b, Simona Luzzi a, Sergio Della Sala b  a: Section of Clinical Neurology, Polytechnic University of Marche, Ancona, Italy b: Human Cognitive Neuroscience, Psychology, The University of Edinburgh, UK  Abstract  Background: Temporary memory for objects bound with colours is impaired in patients with Alzheimer’s disease (AD) (Parra et al., 2009). However, temporary memory for coloured items is not affected by age (Brockmole et al., 2008; Parra et al., 2009). How specific is this STM binding impairment in AD, remains unknown. Aims:  To investigate STM binding in AD and non-AD dementias. Methods: A STM binding task was devised requesting participants to remember arrays of common objects, colours, objects and colours as independent features (unbound), or objects bound with colours. Participants’ free recall of the studied items was assessed immediately after a brief presentation. Patients with AD (n = 15), Fronto-Temporal Dementia (n = 14), Parkinson Dementia (n = 10) and Vascular Dementia (n = 9) matched for demographic and neuropsychological background, and an age and education matched sample of healthy older adults (n = 21) entered the study. All patients were assessed with 4 single, 4 unbound items or 2 bound items, whereas healthy elderly with 8 single, 8 unbound items or 4 bound items. Results: a two-way mixed ANOVA revealed significant effects of Group and an interaction between Group and Stimuli (i.e., single vs. unbound vs. bound items). The interaction was solely driven by AD patients performing worse than the other groups in the binding condition only. Performance in the binding condition was dramatically worse than in the single and unbound items conditions only in AD patients. Conclusions: STM binding is affected in AD patients but is spared in healthy older adults and non-AD dementias. This suggests that STM binding deficits are specific to AD.  Brockmole, J., Parra, M.A., Della Sala, S., & Logie, R. (2008). Do Binding Deficits Account for Age-Related Decline in Visual Working Memory? Psychonomic Bulletin & Review, 15, 543-547.  Parra, M.A., Abrahams, S., Logie, R., & Della Sala, S., (2009). Age and binding within-dimension features in visual short term memory. Neuroscience Letters, 449, 1-5.  Parra, M.A., Abrahams, S., Fabi, K., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short term memory binding deficits in Alzheimer’s Disease. Brain, 132, 1057–1066.  SIN Congress - 2009 

Short-term memory binding in Alzheimer’s Disease and other non-Alzheimer dementia

https://strathprints.strath.ac.uk/66025/1/Fabi_etal_CINS2009_Short_term_memory_binding_in_Alzheimers_Disease_and_other.pdf

Short-term memory binding in Alzheimer’s Disease and other non-Alzheimer dementia

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