Adrian, P.V.

Amyes, S.G.B.

Du Plessis, M.

Klugman, K.P.

The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3'')-Ia], and sulfonamide resistance, sulI, were located downstream of dfrXV in a manner identical to that in pLMO229

Edinburgh Research Explorer

New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron

https://www.pure.ed.ac.uk/ws/files/8663147/New_trimethoprim_resistant_dihydrofolate_reductase_cassette_dfrXV_inserted_in_a_class_1_integron.pdf

New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron

Abstract

Similar works

Full text

Available Versions

Edinburgh Research Explorer