Effect of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c] quinazolin-6-yl) propanoic acid and bemityl on biochemical processes in rats organism in the conditions of the daily training with running in treadmill

Abstract

Department of Pharmacology, N. I. Pirogov National Medical University of Vinnitsa, UkraineBackground: The limited arsenal of actoprotectors by almost one bemethyl has caused the necessity to search the substances with the above action, suitable for the creation of a new drug on their basis. Material and methods: For the investigation the substances of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c]quinazolin-6-yl) propane acid with the laboratory ciphers MT-279 has been taken. The studies have been performed on 56 nonlinear male rats in the conditions of the 15-daily physical loading which promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Results: It has been established that the course (15 days) intraperitoneal injections in rats with sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4] triazine[2,3-c]quinazolin-6-yl) propane acid (MT-279, 2.5 mg/kg), as well as bemethyl (33 mg/kg) promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Conclusions: The compound MT-279 has the largest actoprotective effect virtually mapped to bemethyl. A complex of effects inherent of MT-279 compound indicates the advisability of the in-depth study of its pharmacological properties to find out its safety and suitability for creating a new drug on its basis