Cummings, RD

Gomord, [No Value]

Kooyman, FNJ

van den Berg, TK

van Die, Irma

Vervelde, L

English

Synthesis of parasite specific IgE plays a critical role in the defence against helminth infections. We report here that IgE from serum from Schistosoma mansoni infected mice and Haemonchus contortus infected sheep recognizes complex-type N-glycans from Arabidopsis thaliana, which contain R-GlcNAc beta 1--&gt;4(Fuc alpha 1 --&gt;3)GlcNAc beta 1-Asn (core alpha 1--&gt;3-Fuc) and Xyl beta 1-2Man beta 1 --&gt; 4GlcNAc beta 1-R (core beta 1 --&gt; 2-Xyl) modifications, and honeybee phospholipase A2, which carries N-glycans that contain the core alpha 1--&gt;3-Fuc epitope, Evidence is presented that core alpha 1--&gt;3-fucosylated N-glycans bind a substantial part of the parasite specific IgE in serum of H, contortus infected sheep. These results suggest that the core alpha 1--&gt;3-Fuc antigen may contribute to induction of a Th2 response leading to the production of IgE, In addition we show here that IV-glycans carrying core alpha 1--&gt;3-Fuc and beta 1--&gt;2-Xyl antigens are synthesized by many parasitic helminths and also by the free living nematode Caenorhabditis elegans. Since N-glycans containing the core alpha 1--&gt;3-Fuc have also been implicated in honeybee and plant induced allergies, this conserved glycan might represent an important common IgE epitope, (C) 1999 Federation of European Biochemical Societies.</p

Edinburgh Research Explorer

in: Glycoproteins and Disease

Core alpha 1 -&amp;gt; 3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep

Core alpha 1 -&gt; 3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep

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Core alpha 1 -&amp;gt; 3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep

Abstract

Similar works

Full text

Available Versions

Edinburgh Research Explorer

Core alpha 1 -> 3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep