A Darvasi

A Sewalem

AS Law

B York

BA Taylor

CH Warden

CO Ikeobi

CS Haley

D Pomp

DB West

DW Drolet

ES Lander

GA Brockmann

GA Churchill

GL Sharp

IM Hastings

J Hasegawa

JB Kaam Van

JK Christians

JM Cheverud

JZ Gu

K Kosuga

KH Morris

L Bünger

M Mehrabian

ME Legare

PD Keightley

PM Visscher

PW Laird

S Cases

S Hofmann

S Horvat

SAS Institute

SM Duthie

SO Freytag

T Rankinen

Y Wang

YC Chagnon

Stylianou, IM

Christians, J

Keightley, PD

Bunger, L

Clinton, M

Bulfield, G

Horvat, S

SRUC - Scotland's Rural College

Genetic complexity of an obesity QTL (Fob3) revealed by detailed genetic mapping

Obesity is proving to be a serious health concern in the developed world as well as an unwanted component of growth in livestock production. While recent advances in genetics have identified a number of monogenic causes of obesity, these are responsible for only a small proportion of human cases of obesity. By divergent selection for high and low fat content over 60 generations, we have created Fat (F) and Lean (L) lines of mice that represent a model of polygenic obesity similar to the situation in human populations. From previous crosses of these lines, four body fat quantitative trait loci (QTL) were identified. We have created congenic lines (F(chr15L)), by recurrent marker-assisted backcrossing, to introgress the QTL region with the highest LOD score, Fob3 on Chr 15, from the L-Iine into the F-line background. We have further mapped this QTL by progeny testing of recombinants, produced from crosses between the F-line and congenic F(chrl5L) mice, showing that the Fob3 QTL region is a composite of at least two smaller effect QTL-the proximal QTL Fob3a is a late-onset obesity QTL, whereas the distal Fob3b is an early-onset obesity QTL

Stylianou, Ioannis M

Christians, Julian K

Keightley, Peter D

Bünger, Lutz

Clinton, Michael

Bulfield, Grahame

Horvat, Simon

Edinburgh Research Explorer

Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping

Crossref

Genetic complexity of an obesity QTL (Fob3) revealedby detailed genetic mapping

Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping

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SRUC - Scotland's Rural College

SRUC - Scotland's Rural College

Edinburgh Research Explorer

Crossref