Hypoxia in prostate tumours has been associated with disease progression andmetastasis. MicroRNAs are short noncoding RNA molecules that are important inseveral cell processes, but their role in hypoxic signalling is still poorly understood.miR‐210 has been linked with hypoxic mechanisms, but this relationship has been poorly characterised in prostate cancer. In this report, the link between hypoxia and miR‐210 in prostate cancer cells is investigated. Polymerase chainreaction analysis demonstrates that miR‐210 is induced by hypoxia in prostatecancer cells using in vitro cell models and an in vivo prostate tumour xenograftmodel. Analysis of The Cancer Genome Atlas prostate biopsy datasets shows that miR‐210 is significantly correlated with Gleason grade and other clinical markers of prostate cancer progression. Neural cell adhesion molecule (NCAM) isidentified as a target of miR‐210, providing a biological mechanism wherebyhypoxia‐induced miR‐210 expression can contribute to prostate cancer. This studyprovides evidence that miR‐210 is an important regulator of cell response tohypoxic stress and proposes that its regulation of NCAM may play an importantrole in the pathogenesis of prostate cancer
