Fishlock, Sam

Lee, Chengkuo

Lubarsky, Gennady

McLaughlin, James

Navarro-Paredes, Cesar

Puttaswamy, Srinivasu

Raj, Shasidran

Steele, David

English

The present work designed to fabricate, characterize and use maltose microneedles for blood sampling application. Sugar microneedle was fabricated by drawing lithography technique and investigated for mechanical properties and required dimensions. Microneedle was subjected to plasma treatment to enhance hydrophilicity for rapid transport of bio sample

Ulster University's Research Portal

    Abstract— The present work designed to fabricate, characterize and use maltose microneedles for blood sampling application. Sugar microneedle was fabricated by drawing lithography technique and investigated for mechanical properties and required dimensions. Microneedle was subjected to plasma treatment to enhance hydrophilicity for rapid transport of bio sample.  I. INTRODUCTION Routine blood sampling is crucial for medical diagnosis to understand, prevent, and treatment of specific disease. It can provide critical information such as level of blood components, specific biomarker and improvements after treatment[1]. Many previous studies have been focussed on employing microneedles for body fluid sampling, highlighting its advantages compared to conventional hypodermic needles [2]. Biocompatible microneedles are fabricated using various methods. Maltose is a safe material for both body fluid sampling and drug delivery application[3]. II. METHODS Microneedle is fabricated by inexpensive, simple stepwise drawing lithography technique[4]. The fabricated microneedle was investigated for mechanical properties to ensure it is strong enough to perforate skin when employed for blood sampling.   Figure 1.  Moltose microneedles withSEM image showing tip of microneedle.  aConnected Health Innovation Centre, Engineering Research Institute,   Ulster University, Newtownabbey, United Kingdom bSingapore Institute for Neurotechnology, Centre for Life Sciences, National University of Singapore cDepartment of Electrical and Computer Engineering, National University of Singapore email: srini@ulster.ac.uk    Figure 2.  Moltose microneedles investigated for mechanical properties.  Figure 3.  Superhydrophilic behaviour of moltose microneedle. III. DISCUSSION & CONCLUSION  Super hydrophilic properties of plasma treated microneedle is demonstrated as shown in Figure 3. Microneedle integrated with glass capillary tube was brought in contact with the liquid. With in a short span of 10 seconds, the liquid sample is drawn from tip towards base of microneedle demonstrating its suitability for proposed application. The developed microneedle can be conveniently integrated with lateral flow device for biomedical diagnostic application.  ACKNOWLEDGMENT This work was supported by funding under the Invest Northern Ireland and the European Union’s INTERREG VA Programme, managed by the Special EU Programmes Body (SEUPB) under the Connected Health Innovation Centre (CHIC) competence center  REFERENCES [1] P. Xue, L. Zhang, Z. Xu, J. Yan, Z. Gu, and Y. Kang, “Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics,” Appl. Mater. Today, vol. 13, pp. 144–157, 2018. [2] T. Miyano et al., “Sugar micro needles as transdermic drug delivery system,” Biomed. Microdevices, vol. 7, no. 3, pp. 185–188, 2005. [3] K. Takeuchi, N. Takama, B. Kim, K. Sharma, O. Paul, and P. Ruther, “Microfluidic chip to interface porous microneedles for ISF collection,” Biomed. Microdevices, vol. 21, no. 1, p. 28, 2019. [4] K. Lee and H. Jung, “Drawing lithography for microneedles: a review of fundamentals and biomedical applications,” Biomaterials, vol. 33, no. 30, pp. 7309–7326, 2012.  Smart maltose microneedle for blood sampling fabricated by stepwise controlled drawing Srinivasu Valagerahally Puttaswamya, Sam Jeffery Fishlocka, David Steelea, Cesar Navarro a, Gennady Lubarsky a, Shasidran Raj a,  Chengkuo Leeb,c and James McLaughlina 

Smart maltose microneedle for blood sampling fabricated by stepwise controlled drawing

https://pure.ulster.ac.uk/ws/files/77211001/Abstract_I_PAGE_POSTER_01.05.2019.pdf

Smart maltose microneedle for blood sampling fabricated by stepwise controlled drawing

Abstract

Similar works

Full text

Available Versions

Ulster University's Research Portal