Appleman, JR

Blakley, RL

Freisheim, JH

Huang, SM

Sheridan, RP

Tan, XH

Thompson, Paul

Venkataraghavan, R

English

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1.	Freisheim JH, Huang S, Prendergast NJ, Tan X, Smith PL, Bullerjahn AME, Thompson P, Delcamp TJ, Appleman JR, Beard WA, Tsay JT, Blakley RL 1990 MUTAGENESIS OF HUMAN DIHYDROFOLATE-REDUCTASE STRUCTURE AS A PROBE OF ENZYME FUNCTION. In: Curtius HC, Ghisla S, Blau N (eds.) Chemistry and Biology of Pteridines 1989: Pteridines and Folic Acid Derivatives, pp 708-715.2.	Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK 1997 The vitamin D hormone and its nuclear receptor: molecular actions and disease states. Journal of Endocrinology 154:S57-S73.     http://joe.endocrinology-journals.org/content/154/3_Suppl/S57.full.pdf+html (​http:​/​​/​joe.endocrinology-journals.org​/​content​/​154​/​3_Suppl​/​S57.full.pdf+html​)3.	Haussler MR, Jurutka PW, Hsieh JC, Thompson PD, Selznick SH, Haussler CA, Whitefield GK 1994 Receptor mediated genomic actions of 1,25(OH)(2)D-3: Modulation by phosphorylation. In: Norman AW, Bouillon R, Thomasset M (eds.) Vitamin D: Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications, pp 209-216.4.	Haussler MR, Jurutka PW, Hsieh JC, Thompson PD, Selznick SH, Haussler CA, Whitfield GK 1995 NEW UNDERSTANDING OF THE MOLECULAR MECHANISM OF RECEPTOR-MEDIATED GENOMIC ACTIONS OF THE VITAMIN-D HORMONE. Bone 17(2):S33-S38.     http://www.sciencedirect.com/science/article/pii/875632829500205R (​http:​/​​/​www.sciencedirect.com​/​science​/​article​/​pii​/​875632829500205R​)5.	Huang SM, Appleman JR, Tan XH, Thompson PD, Blakley RL, Sheridan RP, Venkataraghavan R, Freisheim JH 1990 ROLE OF LYSINE-54 IN DETERMINING COFACTOR SPECIFICITY AND BINDING IN HUMAN DIHYDROFOLATE-REDUCTASE. Biochemistry 29(35):8063-8069.    http://pubs.acs.org/doi/abs/10.1021/bi00487a011 (​http:​/​​/​pubs.acs.org​/​doi​/​abs​/​10.1021​/​bi00487a011​)6.	Jurutka PW, Hsieh JC, Remus LS, Whitfield GK, Thompson PD, Haussler CA, Blanco JCG, Ozato K, Haussler MR 1997 Mutations in the 1,25-dihydroxyvitamin D-3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription factor IIB, in vitro. Journal of Biological Chemistry 272(23):14592-14599.7.	Lee WP, Doherty D, Furmick J, Widener T, Jurutka P, Thompson P 2010 Sentrin/SUMO Specific Proteases as Novel Tissue-Selective Co-Activator Proteins That Modulate Signalling by Vitamin D Receptor and Retinoid X Receptor Alpha. Endocrine Reviews 31(3).8.	Pollock C, Maguire O, Smyth T, McClean S, Martin P, Owen A, Thompson P 2010 Regulation of CYP3A4 and CYP3A5 Expression in Prostate Cells and Modulation of 'Intracrine' Metabolism of Androgens by Liganded Vitamin D Receptor (VDR). Endocrine Reviews 31(3).9.	Tan XH, Huang SM, Ratnam M, Thompson PD, Freisheim JH 1990 THE IMPORTANCE OF LOOP REGION RESIDUES 40-46 IN HUMAN DIHYDROFOLATE-REDUCTASE AS REVEALED BY SITE-DIRECTED MUTAGENESIS. Journal of Biological Chemistry 265(14):8027-8032.10.	Thompson PD, Freisheim JH 1991 CONVERSION OF ARGININE TO LYSINE AT POSITION 70 OF HUMAN DIHYDROFOLATE-REDUCTASE - GENERATION OF A METHOTREXATE-INSENSITIVE MUTANT ENZYME. Biochemistry 30(33):8124-8130.11.	Whitfield GK, Hsieh JC, Nakajima S, Macdonald PN, Thompson PD, Jurutka PW, Haussler CA, Haussler MR 1995 A HIGHLY CONSERVED REGION IN THE HORMONE-BINDING DOMAIN OF THE HUMAN VITAMIN-D-RECEPTOR CONTAINS RESIDUES VITAL FOR HETERODIMERIZATION WITH RETINOID-X-RECEPTOR AND FOR TRANSCRIPTIONAL ACTIVATION. Molecular Endocrinology 9(9):1166-1179.12.	Whitfield GK, Selznick SH, Haussler CA, Hsieh JC, Galligan MA, Jurutka PW, Thompson PD, Lee SM, Zerwekh JE, Haussler MR 1996 Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D-3: Point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Molecular Endocrinology 10(12):1617-1631.

ROLE OF LYSINE-54 IN DETERMINING COFACTOR SPECIFICITY AND BINDING IN HUMAN DIHYDROFOLATE-REDUCTASE

https://pure.ulster.ac.uk/ws/files/11309770/pdt_new_additions.doc

ROLE OF LYSINE-54 IN DETERMINING COFACTOR SPECIFICITY AND BINDING IN HUMAN DIHYDROFOLATE-REDUCTASE

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