Introduction:Diabetes mellitus is a dangerous disease with complications and prevalence of mortality accounting for at least 10% of total health care A few published reports of both in vitro and in vivo studies on the interactions among Zinc (Zn), Alkaline- phosphatase (AP) enzyme activity, Ascorbic acid (AA) and glucose drew attention to their alterations in diabetic statesThe present work was aimed at evaluating the serum Zinc, Alkaline phosphatase and Ascorbic acid levels in Diabetes Mellitus and to statistically correlate the serum values of blood glucose with serum zinc, alkaline phosphatase [ALP] & Ascorbic acid [AA] for finding significance which could help in clinical outcome. Methods: The sample size taken was 94 having both males and females of 22-85 years of age. The study group was divided into the following six categories. Group A: - Control group of 20 normal subjects in the age group of 22-70 years, Group B: -14 IDDM without complication subject in the age group of 22-43 years.Group C: -20 IDDM with nephropathy subject in the age group of 41-85 years. Group D: - 20 NIDDM without complication subject in age group of 37-72 years.Group E:-10 NIDDM with nephropathy subject in age group of 45-65 years.Group F:-10 NIDDM with retinopathy subject in age group of 49-66 years. Some parameters were taken from each individual of this study like estimation of blood glucose [fasting and post prandial] by Asatoor and King method, determination of serum Zn was carried out using atomic absorption spectrophotometry, Serum alkaline phosphatase (AP) activity was determined by the method of King and Armstrong as modified by Kind and King, plasma ascorbic acid is determined using formulae Results:The decrease in serum AA levels and the increase in serum DHA were highly significant. However, no correlations could be demonstrated statistically among the above said parameters in healthy and diabetic subjects.. It is being speculated that the raised serum AP activity may be due to the de-inhibition of activity by lowered serum AA concentrations. Serum Alkaline Phosphatase activity is eliminated in diabetics. It is an indicator of liver function that may be hampered in long term in diabetics. Serum Ascorbic acid is an antioxidant and its levels are decreased in diabetics. Its values can be assayed for monitoring oxidative reaction in diabetics. The estimation of serum zinc is not needed as there is no statistical difference. The need for right eating, exercise and right thinking needs to be stressed, particularly for diabetics.
Keywords: NSAIDs, severe cutaneous adverse reactions (SCARs), cutaneous adverse drug reactions (CADRs), stevens johnson syndrome (SJS), fixed drug eruptions (FDEs), fixed dose combination (FDC), over the counter (OTC
