Denton, K

Ellis, K

Evans, C

Frew, V

Giles, T

Holbrook, M

Hunt, K

Kitchener, H

Levine, T

Mathews, C

Moss, S

Parker, J

Patnick, J

Rebolj, M

Rimmer, J

Sargent, A

Smith, D

Smith, J

Stubbs, R

Tidbury, P

Tidy, J

Tyler, X

Queen Mary Research Online

Primary cervical screening with high risk human papillomavirus testing: observational study

OBJECTIVE: To provide the first report on the main outcomes from the prevalence and incidence rounds of a large pilot of routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous primary liquid based cytology screening.DESIGN: Observational study.SETTING: The English Cervical Screening Programme.PARTICIPANTS: 578 547 women undergoing cervical screening in primary care between May 2013 and December 2014, with follow-up until May 2017; 183 970 (32%) were screened with hrHPV testing.INTERVENTIONS: Routine cervical screening with hrHPV testing with liquid based cytology triage and two early recalls for women who were hrHPV positive and cytology negative, following the national screening age and interval recommendations.MAIN OUTCOME MEASURES: Frequency of referral for a colposcopy; adherence to early recall; and relative detection of cervical intraepithelial neoplasia grade 2 or worse from hrHPV testing compared with liquid based cytology in two consecutive screening rounds.RESULTS: Baseline hrHPV testing and early recall required approximately 80% more colposcopies, (adjusted odds ratio 1.77, 95% confidence interval 1.73 to 1.82), but detected substantially more cervical intraepithelial neoplasia than liquid based cytology (1.49 for cervical intraepithelial neoplasia grade 2 or worse, 1.43 to 1.55; 1.44 for cervical intraepithelial neoplasia grade 3 or worse, 1.36 to 1.51) and for cervical cancer (1.27, 0.99 to 1.63). Attendance at early recall and colposcopy referral were 80% and 95%, respectively. At the incidence screen, the 33 506 women screened with hrHPV testing had substantially less cervical intraepithelial neoplasia grade 3 or worse than the 77 017 women screened with liquid based cytology (0.14, 0.09 to 0.23).CONCLUSIONS: In England, routine primary hrHPV screening increased the detection of cervical intraepithelial neoplasia grade 3 or worse and cervical cancer by approximately 40% and 30%, respectively, compared with liquid based cytology. The very low incidence of cervical intraepithelial neoplasia grade 3 or worse after three years supports extending the screening interval.</p

Rebolj, Matejka

Rimmer, Janet

Denton, Karin

Tidy, John

Mathews, Christopher

Ellis, Kay

Smith, John

Evans, Chris

Giles, Thomas

Frew, Viki

Tyler, Xenia

Sargent, Alexandra

Parker, Janet

Holbrook, Miles

Hunt, Katherine

Tidbury, Penny

Levine, Tanya

Smith, David

Patnick, Julietta

Stubbs, Ruth

Moss, Sue

Kitchener, Henry

King's Research Portal

English

Primary cervical screening with high risk human papillomavirus testing:observational study

https://kclpure.kcl.ac.uk/ws/files/120195866/Primary_cervical_screening_with_REBOLJ_Acc1_Jan2019Epub6Feb2019_GOLD_VoR_CC_BY_.pdf

Primary cervical screening with high risk human papillomavirus testing: observational study

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