Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Ali; Bencherif; Bencherif; Béduer; De Vocht; DeFife; Demidova-Rice; den Dekker; Detrez; Doherty; Dooley; Francos-Quijorna; Freudenberg; Freudenberg; Garbayo; Garbayo; Gordon; Gore; Guglielmetti; Hammond; Hamzei Taj; Hixon; Hoban; Hoornaert; Hoornaert; Hu; Jeon; Jones; Kaufmann; Koshy; Kozakov; Le Blon; Le Blon; Li; Lortat-Jacob; Miron; Moloney; Mottarella; Mulloy; Newland; Newland; Newland; Nie; Ochoa-Repáraz; Olanow; Parameswaran; Pearlman; Reekmans; Roberton; Sakiyama-Elbert; Schirmer; Schirmer; Schroeder-Tefft; Sun; van de Weert; Welzel; Whone; Yadav; Zieris

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Authors: Ali
Bencherif
Bencherif
Béduer
De Vocht
DeFife
Demidova-Rice
den Dekker
Detrez
Doherty
Dooley
Francos-Quijorna
Freudenberg
Freudenberg
Garbayo
Garbayo
Gordon
Gore
Guglielmetti
Hammond
Hamzei Taj
Hixon
Hoban
Hoornaert
Hoornaert
Hu
Jeon
Jones
Kaufmann
Koshy
Kozakov
Le Blon
Le Blon
Li
Lortat-Jacob
Miron
Moloney
Mottarella
Mulloy
Newland
Newland
Newland
Nie
Ochoa-Repáraz
Olanow
Parameswaran
Pearlman
Reekmans
Roberton
Sakiyama-Elbert
Schirmer
Schirmer
Schroeder-Tefft
Sun
van de Weert
Welzel
Whone
Yadav
Zieris
Publication date: 1 January 2020
Publisher: Cambridge : Royal Soc. of Chemistry
Doi

Abstract

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry