We present predictions for heavy-quark production at the Large Hadron
Collider making use of the \msbar and MSR renormalization schemes for the
heavy-quark mass as alternatives to the widely used on-shell renormalization
scheme. We compute single and double differential distributions including QCD
corrections at next-to-leading order and investigate the renormalization and
factorization scale dependence as well as the perturbative convergence in these
mass renormalization schemes. The implementation is based on publicly available
programs, MCFM and xFitter, extending their
capabilities. Our results are applied to extract the top-quark mass using
measurements of the total and differential ttˉ production cross-sections
and to investigate constraints on parton distribution functions, especially on
the gluon distribution at low x values, from available LHC data on
heavy-flavor hadro-production.Comment: 47 pages, 20 figures, 5 table