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Towards the formation of neuro-transistor artificial chemical synapse
Authors
,
C Bartic
+6 more
G Borghs
I Goykhman
N Korbakov
J Shappir
ME Spira
S Yitzchaik
Publication date
1 December 2007
Publisher
Abstract
Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nanolayers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE. ©2007 IEEE
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CUED - Cambridge University Engineering Department
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Last time updated on 15/07/2020