Skin is the mirror which reflects the harmony of internal functions of body. Any change in skin colour disturbs the patient both mentally and physically. Psoriasis is an autoimmune disease in which scaling and itching in the papulosquamous lesion of skin disturbs the daily routine of the patients. Because of its recurrent nature the disease has remained a great problem. There is no certain cure for this disease. Modern medicine provides symptomatic relief but also has side effects in long course. The Ayurvedic diagnosis is considered as Ekakushtha which is a Vata Kapha predominant Kshudrakushtha. Here an effort was made to treat a nineteen years old male diagnosed case of Plaque Psoriasis, by combined Ayurvedic regimen. As the principle of treatment of all types of Kushtha is Sanshodhana along with Sanshamana drugs. In this study initially Vamana karma and then Virechana karma was performed. After Sanshodhana, Sanshamana drugs were given for 40 days. PASI (Psoriasis area severity index) score was taken for assessment parameter of improvement. The skin lesions of the patient was calculated by PASI score before starting the treatment was found to be 35.1 which decreased to 5.4 at the end of treatment. This case report showed that combined Ayurvedic modalities resulted in great improvement in overall condition of the patient with no recurrence since last 1 year

Kumar Sahoo, *Sushanta

Kumari, Neha

Singh, Abhilasha

English

International Journal of Ayurveda and Pharma Research

ISSN: 2322 - 0902 (P) ISSN: 2322 - 0910 (O)      IJAPR | October 2017 | Vol 5 | Issue 10  58 International Journal of Ayurveda  and Pharma Research  Case Study   AYURVEDIC MANAGEMENT OF PSORIASIS: A CASE STUDY Sushanta Kumar Sahoo1*, Abhilasha Singh2, Neha Kumari2 *1Associate Professor, 2Assistant Professor, Dept. of Kaya Chikitsa, Gangasheeel Ayurvedic Medical College and Hospital, Bareilly, (UP), India. ABSTRACT Skin is the mirror which reflects the harmony of internal functions of body. Any change in skin colour disturbs the patient both mentally and physically. Psoriasis is an autoimmune disease in which scaling and itching in the papulosquamous lesion of skin disturbs the daily routine of the patients. Because of its recurrent nature the disease has remained a great problem. There is no certain cure for this disease. Modern medicine provides symptomatic relief but also has side effects in long course. The Ayurvedic diagnosis is considered as Ekakushtha which is a Vata Kapha predominant Kshudrakushtha. Here an effort was made to treat a nineteen years old male diagnosed case of Plaque Psoriasis, by combined Ayurvedic regimen. As the principle of treatment of all types of Kushtha is Sanshodhana along with Sanshamana drugs. In this study initially Vamana karma and then Virechana karma was performed. After Sanshodhana, Sanshamana drugs were given for 40 days. PASI (Psoriasis area severity index) score was taken for assessment parameter of improvement. The skin lesions of the patient was calculated by PASI score before starting the treatment was found to be 35.1 which decreased to 5.4 at the end of treatment. This case report showed that combined Ayurvedic modalities resulted in great improvement in overall condition of the patient with no recurrence since last 1 year. KEYWORDS: Psoriasis, Ekakushtha, PASI score, Ayurvedic management. INTRODUCTIONPsoriasis is a common dermatologic disease, affecting up to 1% of the World’s population,[1] both males and females suffering equally[2]. The word Psoriasis is derived from Greek word ‘Psora’ means ‘itch’ and ‘sis’ meaning ‘acting condition’. Psoriasis is a non-infectious, chronic inflammatory disease of skin, characterized by well-defined erythematous plaques with silvery white scale with a predilection for the extensor surface and scalp, and a chronic fluctuating course[3]. In psoriasis, main abnormality is of increased epidermal proliferation due to excessive multiplication of cells in the basal layers. The transit time of keratinocyte is shortened and epidermal turnover is reduced to 5-6 days from 28-30 days[4]. Even though the aetiology is unknown, the factors involved are genetic, biochemical and immunopathological[5]. Precipitating factors like trauma, infections, sunlight, some drugs and emotions may flare up the disease. As there is no available cure for the disease it has remained a great problem for the patients[6]. Patients not only have physical problems, but also suffer mental and social distress. Diagnosis of the disease is made mainly on the basis of clinical symptoms that is,[7]  Erythematous sharply defined plaques, covered with silvery white scales.  Extensor surface primarily involved such as the knees and elbows.  Koebner’s phenomenon present in the active phase of the disease.  Wornoff’s ring often present in the healing phase of the disease. Auspitz sign and candle grease sign are another classic feature of the disease. The goal of the treatment for the disease is to alleviate symptoms which interfere with the patient’s life both physically and socially. In modern system of medicine coaltar preparations, calcipotriol, retinoid, corticosteroids and ultraviolet radiations are the local measure to manage Psoriasis. The systemic treatment commonly used is photo chemotherapy with PUVA, retinoids, methotrexate and cyclosporine –A and corticosteroids[8]. These medicines usually provide good symptomatic control, but in long term cause a number of unpleasant side effects.  There are several types of Psoriasis which can be related to certain diseases described in Samhitas. While the description of Kushtha is present since Vedic period, Ekakushtha is described in Garuda Purana[9] and almost all Ayurvedic classics after that period i.e. Brihattrayi, Laghutrayi and all texts afterwards. Ekakushtha is mentioned in all Ayurvedic classics under Kshudrakushtha and has predominance of Vata and Kapha dosha[10]. The causative factor of Ekakushtha is same as Kushtha. Dietary factors as Viruddha aahara, excessive consumption of Drava, Snigdha, Guru aahar, Navanna, Vega dharana specially of vomiting are major  Sushanta Kumar Sahoo,  Abhilasha Singh,  Neha Kumari. Ayurvedic management of Psoriasis      IJAPR | October 2017 | Vol 5 | Issue 10  59 aetiologies. Indulgence in sinful act and ill Manovritti (negative mentality) are associated mental factor for causing the disease[11]. Acharya Charaka has mentioned the symptoms of Ekakushtha as Aswedanam, Mahavastu, and Matsyashakalopamam[12] and Acharya Sushruta described its symptoms as Krishna- aruna varnata[13]. The etiological factor leads to vitiation of Tridosha especially Vata and Kapha. These Dosha through Tiryakvahini siras proceed to Bahya rogamarga i.e. Twacha, Rakta, Mamsa, and Lasika and cause the symptoms of disease[14]. Repeated Samshodhana along with Samshamana is main line of treatment[15]. Both Antah parimarjan and Bahiparimarjan therapies have been indicated in Kushtha roga. Aim and Objective - To evaluate the role of Samshodhana and Samshamana karma in management of Psoriasis. Place of study - The present case study was done in the Deptt. of Kayachikitsa, Gangasheel Ayurvedic medical college, Bisalpur road, Bareilly (Uttar Pradesh).  CASE REPORT Basic information of the patient o Age -19 yrs o Religion –Hindu o Socioeconomic status- Middle class o He is a farmer and has mixed diet pattern. Patient has habit of chewing Gutkha (1 packet in 2-3 days). Pradhan Vedana (Chief complaints) Erythematous rashes on both hands, legs, abdomen and lower back since 3 years. Itching in rashes, with scaling on scratching. Vartaman Vyadhivritta (History of present illness) The patient was asymptomatic before 3 years. After that he developed complaint of scaly rashes on his lower abdomen and lower back which gradually progressed and involved his both forelegs and both hands. There is severe itching in the rashes along with burning sensation, and scaling after scratching. On enquiry he told that lesions have no relation to seasonal variation and remained constant for whole year. He took allopathic medication for about 1 year and then Ayurvedic medication for 6 months which provided symptomatic relief till treatment continues, on discontinuity of the treatment again the symptoms aggravated.  Purva Vyadhivritta (History of past illness)  Patient has no significant past history of any chronic illness, burn, trauma or Koebner’s phenomenon. Kulaja Vritta (Family history) Same complaint has occurred in patient’s sister since 2 months (April 2017). Vaiyaktikavritta (Personal history)  Appetite was normal.   Predominant rasa in Ahara was Madhura.   Sleep was disturbed due to itching.   Habit of incomplete evacuation of bowel. On Examination  General condition was fair and afebrile.  Vitals were normal.   Cardiovascular system, respiratory system and per abdomen examinations had shown no deformity.   Prakriti (constitution) was Vatapittaja. Ashtavidha Pariksha  Nadi (pulse) was Vatadhikatridoshaja.   Frequency and colour of Mutra (urine) was normal with no Daha.   Mala (stool) was constipated and feeling of incomplete evacuation was there.  Jihva was Sama (coated), suggesting improper digestion.   Shabda (Speech) was clear and fluent.   Sparsha (touch) was Ruksha.   Drik (eyes) were normal.   Aakriti (appearance) was lean. Integumentary system Examination- Lesions were scaly papules, present on lower abdomen, lower back, both hands and legs. They were symmetrical and well demarcated.  Auspitz sign – present Candle grease sign – Present Diagnosis- On the basis of clinical history and examination the condition was diagnosed as Plaque Psoriasis. Treatment protocol Total duration- 6 months 1. Deepana pachana with Chitrakadi vati 500 mg BD for 5 days. 2. Vamana karma- Abhyantara snehana with Panchtikta ghrita for 5 days in increasing order from 20 ml to 100 ml with cow milk followed by Mridu snehana and Swedana for 2 days. Then Vamana karma was performed by Madanphal and Vacha kwath followed by Samsarjana krama for 7 days.  3. Virechana karma – After completion of Samsarjana krama patient was given normal diet for 15 days and again Aabhyantara snehana was done for 5 days. After Mridu swedana, Virechana karma was performed and again Samsarjana krama for 7 days was done before starting Samshamana drugs. 4. Samshamana therapy- For Samshamana therapy following medicines were used-  Arogyavardhini vati  Gandhak rasayan  Rasamanikya  Panchatikta ghrita guggul  Chopchinyadi churna Int. J. Ayur. Pharma Research, 2017;5(10):58-62      Available online at: http://ijapr.in  60  Khadirarishta  777 oil for local application  Guduchi kwath  Mridu virechana with Avipattikar churna  *PASI Score[17]- The current gold standard for assessment of extensive Psoriasis has been the Psoriasis area severity index (PASI). PASI combines the assessment of the severity of lesions and the area affected into a single score in the range 0 (no disease) to 72 (maximal disease). The PASI is a measure of the average redness, thickness and scaling of the lesions (each graded on a 0-4 scale), weighted by the area of involvement. Steps in generating PASI score a. Divide body into four areas: head, arms, trunk to groin and legs to top of buttocks. b. Generate a percentage for skin covered with psoriatic plaques for each area and convert that to 0-6 scale as bellow.   Percentage Rating scale 00 00 00 - < 10 % 01 10 - < 30 % 02 30 - < 50% 03 50 - <70% 04 70 - <90% 05 90 – 100% 06 c. Generate an average score for the erythema, thickness and scale for each of the areas. d. Sum the score of erythema, thickness and scale for each of the areas. e. Multiply item (c) and (d) for each area and multiply that by 0.1, 0.2, 0.3 and 0.4 for head, arms, trunk and legs respectively. f. Add these scores to get the PASI score. Assessment criteria - The improvement of condition of the patient was assessed on the basis of PASI scale* Before trial  Head and neck Arms Trunk Legs Total Skin area involved score 0.3 0.5 0.5 0.3  Redness 2 3 3 3 Thickening 2 3 3 3 Scaling 2 3 3 3 Total 1.8 9 13.5 10.8 35.1 After 2 months  Head and neck Arms Trunk Legs Total Skin area involved score 0.3 0.5 0.5 0.3  Redness 2 3 3 3 Thickening 1 2 2 2 Scaling 1 2 2 2 Total 1.2 7 10.5 8.4 27.1 After 4 months  Head and neck Arms Trunk Legs Total Skin area involved score 0 0.4 0.2 0.3  Redness 0 2 2 2 Thickening 0 1 1 1 Scaling 0 1 1 1 Total 0 3.2 2.4 4.8 10.4 After 6 months  Head and neck Arms Trunk Legs Total Skin area involved score 0 0.2 0.2 0.2  Redness 0 1 1 1 Thickening 0 1 1 1 Scaling 0 1 1 1 Total 0 1.2 1.8 2.4 5.4   Sushanta Kumar Sahoo,  Abhilasha Singh,  Neha Kumari. Ayurvedic management of Psoriasis      IJAPR | October 2017 | Vol 5 | Issue 10  61  RESULT AND DISCUSSION  Psoriasis is a chronic inflammatory disorder, characterised by the formation of well-defined raised erythematous plaques, with silvery white scales; that preferentially localize on the extensor surfaces. It is correlated with certain diseases in Ayurveda. Here a case of Plaque Psoriasis has been discussed, which is best correlated to Ekakushtha. Ekakushtha is a Kshudra Kustha and have Vata-Kapha dominance and even involvement of Tridosha can be evident from its signs and symptoms. The vitiated Doshas reaches to Shithila dushya like Twaka etc. and results into Sthana samshraya avastha and then produces symptoms of Ekakushtha. Acharya Charaka says that in Kushtha, Shithilta is in whole Twak, while the lesions are produced at the site of enlodgement of Doshas[16]. In this disease onset of Matsyashakalopamam (silvery scales) in Mahavastu (large surface area) along with Aswedana (loss of perspiration) is seen. The line of treatment mentioned in Ayurvedic classics for Kushtha roga are Nidana Parivarjana, Shodhana, Snehana, Swedana, Raktamokshana, Prakriti Vighatana, Shamana, Lepana etc. As Ekakushtha is mostly chronic and Bahudoshajanya, both Shodhana and Shamana therapies has to be followed to provide long lasting results and a better life to patients. As it is a disease of Bahya rogamarga, so both Antahparimarjana and Bahi-parimarjana treatments should be used. Considering the above facts, composite treatment plan was adopted. Initially Abhyantara shodhana was done with Vamana and Virechana karma and after completion of Samsarjana krama, Samshamana treatment was performed.    For the basis of improvement of lesions, PASI scale was considered. Before starting the treatment his PASI score was 35.1. After 2 months it was 27.1, after 4 months it was 10.4. After 6 months treatment his PASI score was 5.4. The patient remained in follow up once every month and his PASI score varied from 3 to 5.4 and have no aggravation of complaints till May 2017.  CONCLUSION This case report showed that combined Ayurvedic regimen is potent and effective in treatment of Psoriasis. No adverse effect and aggravation of the symptoms was found in the patient during and after the treatment. REFERENCES 1. Fauci, Braunwald, Kasper, Hauser, Longo, Jameson, Loscalzo; Harrison’s Principal of Internal Medicine. Vol-1; U.S.A.; 17th edition; McGraw Hill Companies; pg 315. 2. Lee Goldman and Andrew I. Schafer; Goldman’s Cecil medicine.24th Edition; Elsevier Saunders. Eczemas, photodermatoses, Papulosquamous diseases.pg no. 2517. 3. Z. Zaidi and S.W.Lanigan; Dermatology in Clinical practice, 2010 Springer- Verlag London Limited, Immune system of the skin, pg 185. 4. Davidson’s. Principles and practice of medicine. 21st edition. Churchill livin stone publication, 2010, Chapter – (Diseases of the skin) Pg -900. 5. Michael Hertl; Autoimmune diseases of skin; third edition; Springer Wein New York; pg no. 328-331. 6. Dr. Neena khanna; Illustrated synopsis of Dermatology and Sexually transmitted diseases; Ed 2005; Peepee publishers and distributors; Pg no. 38. 7. De Korte J, Sprangers MAG, Mombers FMC et al .Quality of life in patients of Psoriasis: A systemic literature review. J invest Dermatol symp Proc 2004;9:140-7.  8. Fitzpatrick’s. Dermatology in General Medicine; vol- 1; seventh edition; Mc Graw hill Companies; Pg 185. 9. Dr. Ram Shankar Bhattacharya; Garuda Purana: Maharshi Vedvays; Varanasi; Edition 1964, 0510152025303540PASI Scoring35.127.110.45.4Graph showing Degree of improvement in skin lesionsBefore treatment2 months4 months6 monthsInt. J. Ayur. Pharma Research, 2017;5(10):58-62      Available online at: http://ijapr.in  62 Chaukhambha Sanskrit Series (Ga. Pu. 1/164/20) Pg no. 38. 10. Pandit Kashinath Pandey and Dr. Gorakhnath Chaturvedi; Charak Samhita, Savimarsha Vidyotini- Hindi Vyakhya; Varanasi; Ed 2011; Pub- Chaukhamba Sanskrit Sansthana Pg no. 253. (Ch. Chi. 7/29-30). 11. Pandit Kashinath Pandey and Dr. Gorakhnath Chaturvedi; Charak Samhita Poorvardh, Savimarsha Vidyotini- Hindi Vyakhya; Varanasi; Ed 2011; Pub- Chaukhamba Sanskrit Sansthana Pg no. 643. 12. Pandit Kashinath Pandey and Dr. Gorakhnath Chaturvedi; Charak Samhita, Savimarsha Vidyotini- Hindi Vyakhya; Varanasi; Ed 2011; Pub- Chaukhamba Sanskrit Sansthana Pg no. 252. (Ch. Chi. 7/21) (Ch. Chi. 7/41). 13. Kaviraj Ambikadatta Shastri; Sushruta Samhita, Ayurveda tatva sandipika, Varanasi; Ed. 2007; Publication- Chaukhambha Sanskrit Sansthana. Pg no. 321. (S. Ni. 5/10). 14. Dr. Brahmananda Tripathi; Ashtang Hridaya, Nirmala Hindi Tika, Varanasi; Ed. 2010, Pub- Chaukhamba Sanskrit Sansthana pg no. 369. (A. H. Ni. 14/3). 15. Pandit Kashinath Pandey and Dr. Gorakhnath Chaturvedi; Charak Samhita, Savimarsha Vidyotini- Hindi Vyakhya; Varanasi; Ed 2011; Pub- Chaukhamba Sanskrit Sansthana Pg no. 255 (Ch. Chi. 7/21) (Ch. Chi. 7/41). 16. Pandit Kashinath Pandey and Dr. Gorakhnath Chaturvedi; Charak Samhita Poorvardh, Savimarsha Vidyotini- Hindi Vyakhya; Varanasi; Ed 2011; Pub- Chaukhamba Sanskrit Sansthana Pg no. 643. 17. W sterry, R Paus, W Burgdorf; Sterry dermatology; Ed 2006; Thieme; New York; Pg 267.        Disclaimer: IJAPR is solely owned by Mahadev Publications - A non-profit publications, dedicated to publish quality research, while every effort has been taken to verify the accuracy of the content published in our Journal. IJAPR cannot accept any responsibility or liability for the articles content which are published. The views expressed in articles by our contributing authors are not necessarily those of IJAPR editor or editorial board members.  Cite this article as:  Sushanta Kumar Sahoo,  Abhilasha Singh,  Neha Kumari. Ayurvedic management of Psoriasis: A case study. International Journal of Ayurveda and Pharma Research. 2017;5(10):58-62. Source of support: Nil, Conflict of interest: None Declared  *Address for correspondence Dr Sushanta Kumar Sahoo Associate Professor, Dept. of Kaya Chikitsa, Gangasheeel Ayurvedic Medical College and Hospital, Bareilly, (UP)., India. Email: sushanta35@gmail.com Ph: 08449335335 

AYURVEDIC MANAGEMENT OF PSORIASIS: A CASE STUDY

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AYURVEDIC MANAGEMENT OF PSORIASIS: A CASE STUDY

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International Journal of Ayurveda and Pharma Research