Urolithiasis is a worldwide problem having no sparing with any group like geographical, cultural or racial. Urinary calculi may cause obstruction, hydronephrosis, infection and hemorrhage in the urinary tract. The management of Urolithiasis with the procedures like surgery, lithotripsy and laser therapy were not only costly but also their recurrence rate are uncertain. But Ayurveda can be the good option to fill this gap with good results. Hence it is necessary and need to explore an Ayurvedic preparation which can resolve this problem with accurate results. And Varun roots and Palash flowers Kwath will be the best option to manage Urolithiasis.Present study was carried out on 30 patients suffering from Urolithiasis. It was a single blind clinical study to evaluate the efficacy of Varun Moola and Palashpushpa Kwath by subjective and objective criteria. 40 ml mixture of decoction was given twice daily for 30 days or till symptoms relieved whichever is earlier.The study revealed that there were significant and positive results of the applied drugs found on the management of Urolithiasis due to its diuretic, anti-infective, anti-biotic and anti-inflammatory properties. These drugs not only reduces symptoms like pain, dysuria, nausea, vomiting, and burning micturition but also helps to reduced pus cells and RBCs in urine as well. This contributes to control urinary tract infection resulting to cure Urolithiasis without producing any adverse effects on patients

Poonam, *Mohod

Sharad, Mohod

Thapa, Anuradha

English

International Journal of Ayurveda and Pharma Research

ISSN: 2322 - 0902 (P) ISSN: 2322 - 0910 (O)  IJAPR | February 2016 | Vol 4 | Issue 2  57 International Journal of Ayurveda  and Pharma Research                                                                           Research Article   FAR-FETCHED PROPERTIES OF VARUN MOOLA (CRATAEVA NURVALA ROOTS) & PALASHPUSHPA (BUTEA MONOSPERMA FLOWERS) TO MANAGE UROLITHIASIS Mohod Poonam1*, Mohod Sharad2, Anuradha Thapa3 *1Associate Professor, 3P.G.Scholar, Department of P.G. Studies in Shalyatantra, Jammu Institute of Ayurveda and Research, Nardni (Raipur), Jammu.  2G.M. Hospital Administration, & Faculty for Research Methodology and Statistics, Jammu Institute of Ayurveda and Research, Nardni (Raipur), Jammu.    ABSTRACT Urolithiasis is a worldwide problem having no sparing with any group like geographical, cultural or racial. Urinary calculi may cause obstruction, hydronephrosis, infection and hemorrhage in the urinary tract. The management of Urolithiasis with the procedures like surgery, lithotripsy and laser therapy were not only costly but also their recurrence rate are uncertain. But Ayurveda can be the good option to fill this gap with good results. Hence it is necessary and need to explore an Ayurvedic preparation which can resolve this problem with accurate results. And Varun roots and Palash flowers Kwath will be the best option to manage Urolithiasis.  Present study was carried out on 30 patients suffering from Urolithiasis. It was a single blind clinical study to evaluate the efficacy of Varun Moola and Palashpushpa Kwath by subjective and objective criteria. 40 ml mixture of decoction was given twice daily for 30 days or till symptoms relieved whichever is earlier.  The study revealed that there were significant and positive results of the applied drugs found on the management of Urolithiasis due to its diuretic, anti-infective, anti-biotic and anti-inflammatory properties. These drugs not only reduces symptoms like pain, dysuria, nausea, vomiting, and burning micturition but also helps to reduced pus cells and RBC’s in urine as well. This contributes to control urinary tract infection resulting to cure Urolithiasis without producing any adverse effects on patients. KEYWORDS: Ashmari, Urolithiasis, Varun Moola (Crataeva nurvala roots), Palashpushpa (Butea monosperma flowers), Kwath, Management. INTRODUCTION  Urolithiasis is one of the most troublesome disorders and is considered as Daruna Vyadhi.[1] It is characterized by the process of calculi (singular of multiple) in the urinary tract. It is more common in the male than that of female. The causes of renal calculi were deficiency of vitamin A, hot climate, decrease in citrate level, infection in kidney, prolong immobilization, hyperthyroidism, hyperoxuluria, cystinurea and stasis due to obstruction in urine flow.[2]  Urolithiasis can be correlated with Mutrashmari as per their signs and symptoms cited in various Ayurvedic texts. It is a disease of Mootravaha strotas. According to the Ayurveda, formation of Mutrashmari is due to drying of Kapha because of the action of Vata and Pitta.[3]  Where as in modern science the stages of stone formation are as follows. [4]            In modern science this disease managed by flush therapy, anti spasmodic, anti-biotic and various advance surgeries like PCNL, ESWL and URS. But limiting factors of these treatments are their cost, availability[5]  and the chance of success. Acharya Sushruta said that, before going for the surgery first try to control the disease with the help of medicine if it is not possible then only go for surgery. The medicinal treatment which is in the form of Churna, Kashaya, Ghrita, and Paniya kshara.  Varuna has anti lithiatic, anti inflammatory, anti biotic[6] and Palashpushpa has diuretic property[7] which would be the great option to control this disease.  These incredible properties insist me to study their role in Urolithiasis.  STATEMENT OF THE STUDY  Role of Varun Moola (Crataeva nurvala roots) & Palashpushpa (Butea monosperma flowers) Kwath in the management of Urolithiasis. AIMS AND OBJECTIVES  1. A conceptual study on Mootrashmari w.s.r.to Urolithiasis and its management. 2. A clinical study on Mootrashmari w.s.r.to Urolithiasis and its management.  SupersatuarationNucleus formationCrystallisation AggregationMatrix FormationSTONEMohod Poonam et al. Far-Fetched Properties of Varun Moola (Crataeva Nurvala Roots) & Palashpushpa (Butea Monosperma Flowers) to Manage Urolithiasis  Available online at: http://ijapr.in  58 3. To evaluate the efficacy of Varun Moola (Crataeva nurvala roots) & Palashpushpa (Butea monosperma flowers) Kwath In the management of Urolithiasis. MATERIALS AND METHODS  It is simple, random, systematic, and focused group study with sample size 30. It was conducted on patients who were suffered from Urolithiasis. The study samples were selected randomly from Department of Shalyatantra of Jammu Institute of Ayurveda & Research. The records of samples under study were maintained according to standardized proforma for quality assurance on regular basis. Inclusion and exclusion criteria were set to achieve and get genuine results of the study.  Inclusion Criteria   1. Patients of age between 20-60 years of both sexes were selected for the study. 2. Only those patients, who were suffering from Urolithiasis, were considered for the study. Exclusion Criteria   1. Patients of both the sexes who were not follows the inclusion criteria for age were excluded from the study. 2. Patients or patients who were suffering from major psychiatric illness, chronic disease and acute condition were excluded from the study. 3. Alcoholic, drug users and drug dependent were also excluded from the study to achieve better results. Drug Medley   The mixture of decoction was given in 40 ml twice daily for 30 days or till symptoms relieved whichever is earlier. The mixture was used to prepare fresh on daily basis, which helps to get and maintain quality output. Prescribed dose of the medicine were as follows.   Varuna Moola Kwath  →  20 ml                  Palashapushpa Kwath →  20 ml           Course of action   All 30 registered, clinically diagnosed and confirmed patients of Urolithiasis have been gone through the above procedure of drug medley. And to achieve the results of the procedure patients were observed on regular basis at least for a month or till the symptoms of the disorder relieved. Meanwhile they were examined thoroughly and their findings were assessed and recorded according to the criteria mentioned in proforma for further analysis.  Follow Up   Patients were followed up after every 7th day and changes, improvements; deterioration and any other effects produced after the therapy were recorded properly for further analysis. Criteria for assessment  Most of the signs and symptoms of Mootrashmari described in Ayurveda are subjective in nature, but some are in objective in nature, which were depend on the investigations like urine (Routine and microscopic), USG (KUB) done before and after treatment. Here, to achieve exact results of the study on the basis of statistical analysis we have been adopted multidimensional scoring system which is as follows. Table 1: Symptoms and grading criteria for Subjective assessment Grade & Meaning Grade Meaning Grade Meaning Grade Meaning Grade Meaning Symptoms 0 Absent 1 Mild 2 Moderate 3 Severe Pain 0 Absent 1 Mild 2 Moderate 3 Severe Nausea 0 Absent 1 Mild 2 Moderate 3 Severe Vomiting 0 Absent 1 Mild 2 Moderate 3 Severe Dysuria 0 Absent 1 Mild 2 Moderate 3 Severe Burning Micturition 0 Absent 1 Mild 2 Moderate 3 Severe Frequency of Micturition (times) 0 2 to 3 1 5 to 6 2 8 to 9 3 >10 Fluid intake in litre 0 Absent 1 < 1 2 < 2 3 > 3  Table 2: Indicators and grading criteria for Objective assessment Symptoms Grade Meaning Grade Meaning Grade Meaning Grade Meaning Site of the Stone 0 Absent 1 Ureter 2 Kidney 3 Both RBC's Count/HPF 0 Absent 1 1 to 5 2 7 to 10 3 >10 Pus Cells 0 Absent 1 1 to 5 2 7 to 10 3 >10 OBSERVATIONS   Study was conducted on 30 established cases of Urolithiasis.  Out of total 30 patients 60% were male and remaining was female.  70% of the patients have drink less than 3 liter fluid daily.  Pain was the prominent symptom found in all patients suffering from Urolithiasis.  90 % of the patients complained that their frequencies of micturition were increased.  70 % of the patients complained burning sensation during micturition.  63.3% of the patients complained symptoms like nausea and dysuria. BD x 30 days Int. J. Ayur. Pharma Research, 2016;4(2):57-61  IJAPR | February 2016 | Vol 4 | Issue 2   59  23.3% of the patients complained vomiting symptom.  93.3 % of the patients have found RBC’s cell in their urine test.  80 % of the patients have found Pus cell in their urine test.  93.3 % of the patients have found single stone in there USG report.  73.3% of the patients have found stone in Ureter in there USG report. DISCUSSION   The disease Mootrashmari can be correlated with urolithiasis. In Ayurvedic literature the cause of this disease was diet having Guru- Snigda aahara and less fluid intake. [8] These food rich in uric acid, calcium, and oxalate which helps in the formation of stones. The highest incidence of Urolithiasis found in male patients than that of female. It may be due to the habits of tea, coffee and tobacco chewing which is more common in males. There is another theory that testosterone hormones also play an important part in the formation of Mootrashmari. Probable mode of action of Varun Moola (Crataeva nurvala roots) and Palashpushpa (Butea monosperma flowers) Table 3: Characteristics of Varun Moola & Palashpushpa Characteristics Varun Moola (Crataeva Nurvala Roots) Palashpushpa (Butea monosperma Flowers) Guna Laghu, Ruksha Laghu, Ruksha Rasa Tikta, Kashaya Katu, Tikta, Kashaya Vipaka Katu Madhur Virya Ushna Shita Prabhava Asmari Bhedana  ---- Karma Ashmari-Bhedana, Mutrala, Mootrakrichchra, Sankarmanapratirodi Mutrala, Mootrjanan, Mootrakrichchra.  Palashpushpa has Madhurvipaka and Shitavirya, it increases urine production and has diuretic property. [9]. It facilitates the calculi to bring downward and flush out the calculi. It is also used in dysuria i.e. difficulty in micturition. Varunmoola has Laghu ruksha property, Tikta kashaya rasa and Ushna virya[10] because of that it absorbed Kleda, and reduces the infection. In case of infection in the kidney- urea splitting organism commonly causes stone formation[11] i.e. E-coli, staphylococcus, streptococcus, proteus etc. Varuna has anti-inflammatory and anti-infective property which not only helps to reduce pain and inflammation but also helps to control UTI too. The best part of the Varun Moola is that, it has Ashmari bhedana prabhava. Due to this property these drugs directly acts on calculi and helps to flush it out resulting to control Urolithiasis.  Varun Moola and Palashpushpa Kwath used for Mootrashmari were highly effective because of their far-fetched properties. Varun especially useful in complaints of urinary systems such as kidney and bladder stones. It has analgesics and anti inflammatory property. Palashpushpa has diuretic property and useful in complaints like difficulty in micturition. The symptoms of Mootrashmari pain, dysuria, burning micturition were controlled by these drugs. Nausea and vomiting are associated with pain frequency. When pain reduced, the symptoms like nausea and vomiting also reduced and diminished.   The effectiveness of the treatment were concluded on the base of comparing before treatment and after treatment scores of subjective and objective criteria RESULTS  Statistical Analysis  Statistical analysis was conducted on SPSS software, paired sample t- test were used to find out the significant level of these drugs. By comparing before and after statistics at 95% confidence level it showed that almost all pairs were statistically significant.  Table 4: Paired sample t- test and statistics S. No. Symptoms of Urolithiasis Separate Samples Statistics Paired Differences Mean SD SEM Mean SD SEM t Sig. (2-tailed) BT AT BT AT BT AT Pair 1 Pain 1.700 0.200 0.651 0.407 0.119 0.074 1.500 0.509 0.093 16.155 0.000 Pair 2 Nausea 0.733 0.167 0.640 0.379 0.117 0.069 0.567 0.504 0.092 6.158 0.000 Pair 3 Vomiting 0.267 0.067 0.521 0.254 0.095 0.046 0.200 0.407 0.074 2.693 0.012 Pair 4 Dysuria 0.833 0.167 0.747 0.379 0.136 0.069 0.667 0.547 0.100 6.679 0.000 Pair 5 Burning Micturition 1.033 0.200 0.809 0.407 0.148 0.074 0.833 0.648 0.118 7.047 0.000 Pair 6 Frequency of Micturition 1.400 0.433 0.770 0.504 0.141 0.092 0.967 0.414 0.076 12.794 0.000 Pair 7 RBC’s 1.433 0.333 0.774 0.479 0.141 0.088 1.100 0.481 0.088 12.535 0.000 Pair 8 Pus cells 1.167 0.233 0.791 0.430 0.145 0.079 0.933 0.583 0.106 8.764 0.000 Mohod Poonam et al. Far-Fetched Properties of Varun Moola (Crataeva Nurvala Roots) & Palashpushpa (Butea Monosperma Flowers) to Manage Urolithiasis  Available online at: http://ijapr.in  60 Statistical analysis shows that there are significant differences on the symptoms occur in before and after treatment values; which indicate that Varunmoola Kwath is highly significant on the management of Urolithiasis.   Here it was seen that after completion of the course 80% of the patient’s relieved from Pain, RBC & Pus cell count were reduces in the patients 57.6% and 50.8% respectively, Frequency and burning micturition were controlled by 41.9% and 41.4% in the patient after treatment. Symptoms like Nausea and Dysuria were controlled after treatment it was 37% in both symptoms. Lastly 21.3% of the patients show reduces in the symptoms of vomiting. Table 5: Improvement statistics of Urolithiasis symptoms Symptoms of Urolithiasis Before Treatment After Treatment Improvement Frequency % Frequency % Frequency % Pain  30 100.00 6 20 24 80.0 Nausea  19 63.33 5 26 14 37.0 Vomiting  7 23.33 2 2 5 21.3 Dysuria 19 63.33 5 26 14 37.0 Burning micturition 21 70.00 6 29 15 41.4 Frequency of micturition  27 90.00 13 48 14 41.9 RBC' count in urine 28 93.33 10 36 18 57.6 Pus cell count in urine 24 80.00 7 29 17 50.8   CONCLUSION   The present study revealed that Urolithiasis is worldwide problem. Varunmoola has lithotriptic, diuretic, anti-infective, anti-biotic and anti-inflammatory properties and Palashpushpa has diuretic property. It was found that these drugs have lithotriptic action which expel out calculi from urinary tract. Decoction of Varun Moola and Palashpushpa reduced pain, dysuria, nausea, vomiting, burning micturition, pus cells and RBC’s in urine. Due to these incredible properties these drugs were found efficacious in the management of Mootrashmari. However with respect to size and site of stone no much change were observed. These drugs are economical and highly effective without producing any adverse effects.  REFERENCES  1. Sushruta, Sushruta Samhita, Part-I, Ayurveda Tatwa Sandeepika Hindi Commentary, Edited by Kaviraj Ambika Dutta Shastri, Chikitsasthana- 7/3, Chaukhamba Sanskrit Sansthan, Varanasi, Edition-13, 2002, Page no.-41. 2. Sriram Bhat M, SRB’s manual of surgery, 4th edition (2013), Jaypee medical publishers (P) ltd, New Delhi, Page no.-1090. 3. Sushruta, Sushruta Samhita, Part-I, Ayurveda Tatwa Sandeepika Hindi Commentary, Edited by Kaviraj Ambika Dutta Shastri, Nidanasthana- 3/26, Chaukhamba Sanskrit Sansthan, Varanasi, Edition-13, 2002, Page no.-243. 4. Sriram Bhat M, SRB’s manual of surgery, 4th edition (2013), Jaypee medical publishers (P) ltd, New Delhi, Page no.-1090. 100.063.323.363.370.090.0 93.380.002026226 2948362980.037.021.337.041.4 41.957.650.80.020.040.060.080.0100.0120.0Pain Nausea Vomitting Dysuria Burning micturitionFrequency of micturition (times) RBC' in urine Pus in urineChart No-1:-Statestics of Urolithiasis Before TreatmentAfter TreatmentImprovementInt. J. Ayur. Pharma Research, 2016;4(2):57-61  IJAPR | February 2016 | Vol 4 | Issue 2   61 5. Sriram Bhat M, SRB’s manual of surgery, 4th edition (2013), Jaypee medical publishers (P) ltd, New Delhi, Page no.-1092. 6. K.M. Nadkarni, Indian Materia Medica (1999) Vol-1, Popular Prakashan Private Limited, Mumbai, 3 edition, Page no.-387-388. 7. K.M. Nadkarni, Indian Materia Medica (1999) Vol-1, Popular Prakashan Private Limited, Mumbai, 3 edition, Page no.-223-224. 8. Sushruta, Sushruta Samhita, Part-I, Ayurveda Tatwa Sandeepika Hindi Commentary, Edited by Kaviraj Ambika Dutta Shastri, Nidanasthana, - 3/4, Chaukhamba Sanskrit Sansthan, Varanasi, Edition-13, 2002, Page no.-240. 9. P.V.Sharma, Dravya guna vignana, Vol.2 (2005), Chaukhambha bharti academy, Varanasi, Page no.-507-508. 10. P.V.Sharma, Dravya guna vignana, Vol.2 (2005), Chaukhambha bharti academy, Varanasi, Page no.-656. 11. Sriram Bhat M, SRB’s manual of surgery, 4th edition (2013), Jaypee medical publishers (P) ltd, New Delhi, Page no.-1090.  Cite this article as:  Mohod Poonam, Mohod Sharad, Anuradha Thapa. Far-Fetched Properties of Varun Moola (Crataeva Nurvala roots) & Palashpushpa (Butea Monosperma Flowers) to Manage Urolithiasis. International Journal of Ayurveda and Pharma Research. 2016;4(2):57-61. Source of support: Nil, Conflict of interest: None Declared  *Address for correspondence Dr. Poonam Mohod  Associate Professor,   Department of PG Studies in Shalyatantra, Jammu Institute of Ayurveda & Research, Nardni (Raipur), Jammu, India.  Email: poonarnawa@yahoo.com  Ph: 09596724047  

FAR-FETCHED PROPERTIES OF VARUN MOOLA (CRATAEVA NURVALA ROOTS) & PALASHPUSHPA (BUTEA MONOSPERMA FLOWERS) TO MANAGE UROLITHIASIS

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FAR-FETCHED PROPERTIES OF VARUN MOOLA (CRATAEVA NURVALA ROOTS) & PALASHPUSHPA (BUTEA MONOSPERMA FLOWERS) TO MANAGE UROLITHIASIS

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