Objectives: To evaluate whether gamma-glutamyl transferase can be used as a new novel bone resorption marker in postmenopusal osteoporotic subjects. Design and methods: 156 postmenopausal subjects were divided into three groups according to their lumbar spine T-score measured by dual-energy X-ray absorptiometry as normal, (control group, n=56), osteopenic (n=50) and osteoporotic (n=50). Deoxypyridinoline and gamma-glutamyl transferase from urine samples and osteocalcin and bone specific alkaline phosphates from blood samples were assessed. Results: Osteocalcin and bone specific alkaline phosphates levels were increased in osteoporotic group (p0.05). No significant correlation was found between urinary gamma-glutamyl transferase and deoxypyridinoline, bone specific alkaline phosphates and osteocalcin (p>0.05). Urinary gamma-glutamyl transferase levels showed no significant correlation with neither bone mineral density nor T scores in all subjects (r=0.058 p=0.625, r=-0.074 p=0.533 respectively). Conclusions: Our primary findings did not support the suggestion that urinary g-glutamyl transferase could be used as a potential marker for bone resorption in postmenopusal osteoporotic subjects
