PRAC and VM are partially supported by the Brazilian research agencies CNPq. PRAC received financial support from Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE) Proj. No. APQ-0464-1.05/15. FFF is supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Proj. No. 2013/18942-2. WH received funding from Cancer Research UK (No. TBYG1P5R) and the Max Planck Society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript