The Mexican axolotl (Ambystoma mexicanum) is one of the
most widely used laboratory animals for research. It is able
to regenerate multiple structures including the limbs, jaws,
tail, spinal cord and skin among other organs. The mechanisms
governing regeneration, wound healing, development,
and cancer formation are closely linked. There is increasing
evidence highlighting the common signalling pathways
which link to cancer growth and regeneration whereby dysregulation
of the well-balanced and coordinated process of
regeneration leads to cancer. This review aims to highlight
the regenerative capacity of axolotls and identify how the
active molecules from regeneration extracts could lead to
major benefits, with directions on how to develop therapeutic
approaches for cancer treatment in humans.peer-reviewe
